T–cell memory: lessons from Epstein–Barr virus infection in man

• Published in: Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 355; no. 1395; pp. 391 - 400
• Main Authors: Rickinson, A. B., Callan, M. F. C., Annels, N. E.
• Format: Journal Article
• Language: English
• Published: England The Royal Society 29-03-2000
• Subjects: Animals; Antigens; Antigens, Viral - immunology; B lymphocytes; cytotoxicTcells; Epitopes; Epstein Barr virus infections; Epstein-Barr virus; Herpesviridae Infections - epidemiology; Herpesviridae Infections - genetics; Herpesviridae Infections - immunology; Herpesvirus 4, Human - immunology; Human herpesvirus 4; Humans; Immunologic Memory - immunology; Infections; infectious mononucleosis; Memory; persistent infection; Persistent Infection and Immunological Memory; primary infection; T cell antigen receptors; T lymphocytes; T-cell memory; T-Lymphocytes, Cytotoxic - immunology; Tumor Virus Infections - epidemiology; Tumor Virus Infections - genetics; Tumor Virus Infections - immunology; Virus Latency - immunology; Viruses
• ISSN: 0962-8436; 1471-2970
• DOI: 10.1098/rstb.2000.0579

Epstein-Barr virus offers an ideal opportunity to follow the human T-cell response to a virus infection over time from its acute primary phase, as seen in infectious mononucleosis patients, into the memory phase that accompanies life-long virus persistence. Here we review recent evidence on the development and maturation of cytotoxic T-cell memory using this viral system.