The trouble with spines in fragile X syndrome: density, maturity and plasticity

Highlights ► Defects in the density, shape and turnover of spines occur in FXS. ► How these lead to circuit dysfunction and cognitive-behavioral symptoms is unknown. ► There are still several controversies regarding the exact spine defects in FXS. ► The real problem may be a defect in activity-depen...

Full description

Saved in:

Bibliographic Details
Published in:	Neuroscience Vol. 251; pp. 120 - 128
Main Authors:	He, C.X, Portera-Cailliau, C
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 22-10-2013
Subjects:	Animals Brain - pathology Dendritic Spines - pathology Disease Models, Animal filopodia Fmr1 fragile X mental retardation protein Fragile X Syndrome - pathology metabotropic glutamate receptor Mice Mice, Knockout Neurology Neuronal Plasticity synaptic plasticity two-photon FXS metabotropic glutamate receptor fragile X syndrome Fmr1 LTP L layer mGluR GFP P electron microscopy postnatal day fragile X mental retardation protein WT filopodia knockout two-photon KO FMRP long-term depression EM green fluorescent protein Div days in vitro synaptic plasticity wild-type LTD long-term potentiation
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Highlights ► Defects in the density, shape and turnover of spines occur in FXS. ► How these lead to circuit dysfunction and cognitive-behavioral symptoms is unknown. ► There are still several controversies regarding the exact spine defects in FXS. ► The real problem may be a defect in activity-dependent spine plasticity/maturation. ► Future research should explore further spine integrity and plasticity in FXS.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.03.049