The effects of diet‐induced obesity on B cell function

• Published in: Clinical and experimental immunology Vol. 179; no. 1; pp. 90 - 99
• Main Authors: Shaikh, S. R., Haas, K. M., Beck, M. A., Teague, H.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01-01-2015; Blackwell Science Inc
• Subjects: Adipose Tissue - immunology; Adipose Tissue - pathology; Animals; Antigens, Surface - metabolism; B cell; B-Lymphocyte Subsets - cytology; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; B-Lymphocytes - cytology; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Cell Differentiation; Comorbidity; diabetes; Diet; Fatty acids; Fatty Acids, Unsaturated - metabolism; Humans; Immune system; Immunity, Humoral; inflammation; Inflammation - immunology; Inflammation - metabolism; Inflammation - pathology; lipid mediators; Obesity; Obesity - etiology; Phenotype; Review; Rodents; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; B cell; lipid mediators; inflammation; diabetes
• ISSN: 0009-9104; 1365-2249
• DOI: 10.1111/cei.12444

Summary
B‐1 and B‐2 B cell subsets carry out a diverse array of functions that range broadly from responding to innate stimuli, antigen presentation, cytokine secretion and antibody production. In this review, we first cover the functional roles of the major murine B cell subsets. We then highlight emerging evidence, primarily in preclinical rodent studies, to show that select B cell subsets are a therapeutic target in obesity and its associated co‐morbidities. High fat diets promote accumulation of select murine B cell phenotypes in visceral adipose tissue. As a consequence, B cells exacerbate inflammation and thereby insulin sensitivity through the production of autoantibodies and via cross‐talk with select adipose resident macrophages, CD4+ and CD8+ T cells. In contrast, interleukin (IL)‐10‐secreting regulatory B cells counteract the proinflammatory profile and improve glucose sensitivity. We subsequently review data from rodent studies that show pharmacological supplementation of obesogenic diets with long chain n‐3 polyunsaturated fatty acids or specialized pro‐resolving lipid mediators synthesized from endogenous n‐3 polyunsaturated fatty acids boost B cell activation and antibody production. This may have potential benefits for improving inflammation in addition to combating the increased risk of viral infection that is an associated complication of obesity and type II diabetes. Finally, we propose potential underlying mechanisms throughout the review by which B cell activity could be differentially regulated in response to high fat diets.