Dietary insulin index, dietary insulin load and dietary patterns and the risk of metabolic syndrome in Hoveyzeh Cohort Study

• Published in: Scientific reports Vol. 14; no. 1; pp. 1968 - 14
• Main Authors: Elyasi, Leila, Borazjani, Fatemeh, Ahmadi Angali, Kambiz, Hosseini, Seyed Ahmad, Saki, Nader
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23-01-2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308/174; 692/700/2814; Adult; Cohort analysis; Cohort Studies; Cross-Sectional Studies; Deserts; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2; Diet; Dietary Patterns; Female; Fruits; Generalized linear models; Grain; Humanities and Social Sciences; Humans; Hyperlipidemia; Insulin; Insulin secretion; Iran; Magnesium; Male; Metabolic disorders; Metabolic Syndrome; multidisciplinary; Science; Science (multidisciplinary); Sugar; Sugars; Sweet taste; Women; Iran
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-52263-5

Postprandial insulin secretion has been associated with metabolic disorders such as hyperlipidemia and type 2 diabetes. Therefore, we aimed to explore the relationship between dietary insulin indices and dietary pattern with the risk of Metabolic Syndrome (MetS). The participants of the present cross-sectional study were included among the individuals who participated in the Hoveyzeh Cohort Study (HCS). A total of 3905 Iranian adults, aged 35–70 years, are included in the current analysis. The Food Frequency Questionnaire (FFQ) is used to calculate the dietary Insulin Index (DII), Insulin Load (DIL), and dietary pattern. Dietary pattern was derived using Reduced-Rank Regression (RRR) based on intake of protein (g/day), fiber (g/day), fat (g/day), magnesium (mg/day), and dietary insulin index were considered as response variables. The Generalized Linear Model was used to obtain the odds ratio (OR) and 95% confidence interval (CI) for MetS based on gender, while considering quartiles of DIL, DII scores, and dietary pattern, adjusted for potential confounders. The mean ± SD of age and BMI of the participants in the top quartile of DIL were 45.72 ± 8.05 years and 28.25 ± 5.02 kg/m
2
, respectively. The mean ± SD of DII was 40.53 ± 4.06 and the mean ± SD of DIL was 117,986.1 ± 30,714.06. A significant positive association was observed between DIL and MetS in women after adjusting for confounding factors (OR: 1.51; 95% CI 1.16; 1.96). No significant association was seen between DIL, DII, and MetS among men. A derived dietary pattern characterized by high intakes of fruits, sugar, sweet deserts, Whole Grains, and dairy was associated with an increased risk of MetS in adjusted model2 among women (OR: 1.41; 95% CI 1.13; 1.75) and men in the same model (OR: 2.09; 95% CI 1.35; 3.21).However, the final model was significant just for men (OR: 2.08; 95% CI 1.35; 3.21) and not for women (OR: 1.24; 95% CI 0.96; 1.60). Our findings showed that adherence to a diet with a high insulin load can increase the risk of MetS in women. In addition, a derived dietary pattern by RRR indicated that a diet rich in fruits, sugar, sweet deserts, whole Grains, and dairy is related to increased risk of MetS in both men and women.