Epidemiologic changes of a longitudinal surveillance study spanning 51 years of scrub typhus in mainland China

• Published in: Scientific reports Vol. 14; no. 1; p. 3138
• Main Authors: Peng, Pei-Ying, Duan, Hui-Ying, Xu, Lei, Zhang, Lin-Tao, Sun, Ji-Qin, Zu, Ya, Ma, Li-Juan, Sun, Yan, Yan, Ting-Liang, Guo, Xian-Guo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07-02-2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308/174; 692/699/255; 692/700/478; China - epidemiology; Epidemiology; Farmers; Female; Humanities and Social Sciences; Humans; Incidence; Male; multidisciplinary; Orientia tsutsugamushi; Public health; Science; Science (multidisciplinary); Scrub typhus; Scrub Typhus - epidemiology; Seasons; Sex differences; Spatial Analysis; Spatial distribution; Temporal distribution; Typhus; China
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-53800-y

Scrub typhus may be one of the world’s most prevalent, neglected and serious, but easily treatable, febrile diseases. It has become a significant potential threat to public health in China. In this study we used national disease surveillance data to analyze the incidence and spatial–temporal distribution of scrub typhus in mainland China during 1952–1989 and 2006–2018. Descriptive epidemiological methods and spatial–temporal epidemiological methods were used to investigate the epidemiological trends and identify high-risk regions of scrub typhus infection. Over the 51-year period, a total of 182,991 cases and 186 deaths were notified. The average annual incidence was 0.13 cases/100,000 population during 1952–1989. The incidence increased sharply from 0.09/100,000 population in 2006 to 1.93/100,000 population in 2018 and then exponentially increased after 2006. The incidence was significantly higher in females than males (χ
2
 = 426.32,
P
 < 0.001). Farmers had a higher incidence of scrub typhus than non-farmers (χ
2
 = 684.58,
P
 < 0.001). The majority of cases each year were reported between July and November with peak incidence occurring during October each year. The trend surface analysis showed that the incidence of scrub typhus increased gradually from north to south, and from east and west to the central area. The spatial autocorrelation analysis showed that a spatial positive correlation existed in the prevalence of scrub typhus on a national scale, which had the characteristic of aggregated distribution (
I
 = 0.533,
P
 < 0.05). LISA analysis showed hotspots (High–High) were primarily located in the southern and southwestern provinces of China with the geographical area expanding annually. These findings provide scientific evidence for the surveillance and control of scrub typhus which may contribute to targeted strategies and measures for the government.