Factors influencing the drug release from calcium phosphate cements

• Published in: Bioactive materials Vol. 7; pp. 341 - 363
• Main Authors: Fosca, Marco, Rau, Julietta V., Uskoković, Vuk
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01-01-2022; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Antibiotics release; Bone fillers; Calcium phosphate cements; Drug release; Release rate; Drug release; Bone fillers; Calcium phosphate cements; Release rate; Antibiotics release
• ISSN: 2452-199X; 2452-199X
• DOI: 10.1016/j.bioactmat.2021.05.032

Thanks to their biocompatibility, biodegradability, injectability and self-setting properties, calcium phosphate cements (CPCs) have been the most economical and effective biomaterials of choice for use as bone void fillers. They have also been extensively used as drug delivery carriers owing to their ability to provide for a steady release of various organic molecules aiding the regeneration of defective bone, including primarily antibiotics and growth factors. This review provides a systematic compilation of studies that reported on the controlled release of drugs from CPCs in the last 25 years. The chemical, compositional and microstructural characteristics of these systems through which the control of the release rates and mechanisms could be achieved have been discussed. In doing so, the effects of (i) the chemistry of the matrix, (ii) porosity, (iii) additives, (iv) drug types, (v) drug concentrations, (vi) drug loading methods and (vii) release media have been distinguished and discussed individually. Kinetic specificities of in vivo release of drugs from CPCs have been reviewed, too. Understanding the kinetic and mechanistic correlations between the CPC properties and the drug release is a prerequisite for the design of bone void fillers with drug release profiles precisely tailored to the application area and the clinical picture. The goal of this review has been to shed light on these fundamental correlations.
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•Drug release from calcium phosphate cements (CPCs) for bone healing and regeneration.•Release of antibiotics, anti-inflammatories, chemotherapeutics, growth factors, and metallic ions.•Influence of different CPC formulations, matrix porosity, structure, and crystallinity.•Influence of matrix additives and the release medium.•Influence of the drug type, concentration and loading method.