Usefulness of the Neutrophil to Lymphocyte Ratio in Predicting Long-Term Mortality in ST Segment Elevation Myocardial Infarction

• Published in: The American journal of cardiology Vol. 101; no. 6; pp. 747 - 752
• Main Authors: Núñez, Julio, MD, Núñez, Eduardo, MD, MPH, Bodí, Vicent, MD, Sanchis, Juan, MD, Miñana, Gema, MD, Mainar, Luis, MD, Santas, Enrique, MD, Merlos, Pilar, MD, Rumiz, Eva, MD, Darmofal, Helene, Heatta, Anne M, Llàcer, Angel, MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15-03-2008; Elsevier; Elsevier Limited
• Subjects: Aged; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Cause of Death - trends; Confidence Intervals; Coronary Angiography; Coronary heart disease; Electrocardiography; Female; Follow-Up Studies; Heart; Heart attacks; Humans; Leukocyte Count; Lymphocytes - pathology; Male; Medical imaging; Medical sciences; Middle Aged; Mortality; Myocardial Infarction - blood; Myocardial Infarction - diagnosis; Myocardial Infarction - mortality; Myocarditis. Cardiomyopathies; Neutrophils - pathology; Prognosis; Proportional Hazards Models; Regression analysis; Retrospective Studies; Risk factors; Survival Rate - trends; Time Factors; Myocardial infarction; Prognosis; Mortality; Granulocyte; Cardiovascular disease; Coronary heart disease; Myocardial disease; Epidemiology; Long term; ST elevation; Ratio; Circulatory system; Neutrophil; Cardiology; Lymphocyte
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2007.11.004

Neutrophil to lymphocyte ratio (N/L) has been associated with poor outcomes in patients who underwent cardiac angiography. Nevertheless, its role for risk stratification in acute coronary syndromes, specifically in patients with ST-segment elevation myocardial infarction (STEMI), has not been elucidated. We sought to determine the association of N/L maximum value (N/Lmax ) with mortality in the setting of STEMI and to compare its predictive ability with total white blood cell maximum count (WBCmax ). We analyzed 515 consecutive patients admitted with STEMI to a single university center. White blood cells (WBC) and differential count were measured at admission and daily for the first 96 hours afterward. Patients with cancer, inflammatory diseases, or premature death were excluded, and 470 patients were included in the final analysis. The association between N/Lmax and WBCmax with mortality was assessed by Cox regression analysis. During follow-up, we registered 106 deaths (22.6%). A positive trend between mortality and N/Lmax quintiles was observed; 6.4%, 12.4%, 11.7%, 34%, and 47.9% of deaths occurred from quintiles 1 to 5 (p <0.001), respectively. In a multivariable setting, after adjusting for standard risk factors, patients in the fourth (Q4 vs Q1) and fifth quintile (Q5 vs Q1) showed the highest mortality risk (hazard ratio 2.58, 95% confidence interal 1.06 to 6.32, p = 0.038 and hazard ratio 4.20, 95% confidence interal 1.73 to 10.21, p = 0.001, respectively). When WBCmax and cells subtypes were entered together, N/Lmax remained as the only WBC parameter; furthermore, the model with N/Lmax showed the most discriminative ability. In conclusion, N/Lmax is a useful marker to predict subsequent mortality in patients admitted for STEMI, with a superior discriminative ability than total WBCmax.