Synthesis and insecticide evaluation of some new oxopropylthiourea compounds as insect growth regulators against the cotton leafworm, Spodoptera littoralis

• Published in: Scientific reports Vol. 13; no. 1; p. 13089
• Main Authors: El-Saghier, Ahmed M., Abosella, Laila, Aborahma, Gamal A., Elakesh, Esmail O., Abdelhamid, Antar A., Gad, Mohamed A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11-08-2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/181; 631/535; 631/92; 639/638; Carboxylic acids; Cotton; Fecundity; Growth regulators; Hatchability; Humanities and Social Sciences; Insecticides; Insects; Larvae; multidisciplinary; Organic compounds; Pesticides; Science; Science (multidisciplinary); Spodoptera littoralis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-39868-y

In this project we aim to share in increasing the production of the most important non-food agricultural product i.e. cotton via protection of it is plant. The usage of safe alternatives to the pesticides has become crucial due to several serious issues associated with the use of insecticides. Therefore, the families of new eco-friendly organic compounds that contain manly oxopropylthiourea scaffold will synthesis in their pure state by using green procedures. This compounds includes (i) poly functional substituted oxopropylthiourea, (ii) dihydroquinoline carboxylic acid, In second category, the structure of this compounds which may be related to the most famous insect growth regulators insecticides, will confirmed by elemental and modern spectroscopic analyses (such as IR, UV,
1
HNMR and
13
CNMR). In the final category, the synthesized compounds was checked toward the second & forth instar larvae of cotton leafworm,
Spodoptera littoralis
. The present data proved that values of LC
50
of the most effected synthesized compound
8
was 2.412 ppm in which LC
50
for commercial lufenuron was 2.295 ppm. Component
8
may be particularly effective due to the presence of fluorophenyl, cyanoacetamide, and carboxalic acid groups in their chemical makeup. In an additional effort to slightly improve insecticidal compounds, evaluation of the latent effects of the examined components on a number of biological parameters, such as adult longevity, pupal weight, proportion of normal, deformed pupae, & adult emergency, fecundity, & egg hatchability, was carried out.