Value Set for the EQ-5D-Y-3L in Hungary

• Published in: PharmacoEconomics Vol. 40; no. Suppl 2; pp. 205 - 215
• Main Authors: Rencz, Fanni, Ruzsa, Gábor, Bató, Alex, Yang, Zhihao, Finch, Aureliano Paolo, Brodszky, Valentin
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-12-2022; Springer; Springer Nature B.V
• Subjects: Adolescent; Adult; Adults; Child; Children; Children & youth; Decision making; Health Administration; Health aspects; Health Economics; Health Status; Health status indicators; Health surveys; Health technology assessment; Humans; Hungary; Medicine; Medicine & Public Health; Methods; Original; Original Research Article; Pain; Pharmacoeconomics and Health Outcomes; Polls & surveys; Preferences; Public Health; Quality of Life; Quality of Life Research; Quality-Adjusted Life Years; Surveys; Surveys and Questionnaires; Technology assessment; Teenagers; Valuation; Hungary
• ISSN: 1170-7690; 1179-2027
• DOI: 10.1007/s40273-022-01190-2

Background
The Hungarian health technology assessment guidelines recommend the use of the EuroQol instrument family in quality-adjusted life-year calculations. However, no national value set exists for the EQ-5D-Y-3L or any other youth-specific instrument.
Objective
This study aims to develop a national value set of the EQ-5D-Y-3L for Hungary based on preferences of the general adult population.
Methods
This study followed the international valuation protocol for the EQ-5D-Y-3L. Two independent samples, representative of the Hungarian general adult population in terms of age and sex were recruited to complete online discrete choice experiment (DCE) tasks and composite time trade-off (cTTO) tasks by computer-assisted personal interviews. Adults valued hypothetical EQ-5D-Y-3L health states considering the health of a 10-year-old child. DCE data were modelled using a mixed logit model with random-correlated coefficients. Latent DCE utility estimates were mapped onto mean observed cTTO utilities using ordinary least squares regression.
Results
Overall, 996 and 200 respondents completed the DCE and cTTO surveys, respectively. For each domain, the value set resulted in larger utility decrements with more severe response levels. The relative importance of domains by level 3 coefficients was as follows: having pain or discomfort > feeling worried, sad or unhappy > mobility > doing usual activities > looking after myself. Overall, 12.3% of all health states had negative utilities in the value set, with the worst health state having the lowest predicted utility of − 0.485.
Conclusion
This study developed a national value set of the EQ-5D-Y-3L for Hungary. The value set enables to evaluate the cost utility of health technologies for children and adolescents based on societal preferences in Hungary.