The significance of exosomes in the development and treatment of hepatocellular carcinoma

• Published in: Molecular cancer Vol. 19; no. 1; p. 1
• Main Authors: Li, Xin, Li, Chuanyun, Zhang, Liping, Wu, Min, Cao, Ke, Jiang, Feifei, Chen, Dexi, Li, Ning, Li, Weihua
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04-01-2020; BioMed Central; BMC
• Subjects: Angiogenesis; Animals; Antineoplastic Agents - therapeutic use; B cells; Biomarkers, Tumor - antagonists & inhibitors; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer therapies; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Cellular signal transduction; Communication; Dendritic cells; Deoxyribonucleic acid; Development and progression; Diagnosis; DNA; Drug therapy; Exosomes; Exosomes - genetics; Exosomes - metabolism; Gene Expression Regulation, Neoplastic; Hepatitis; Hepatocellular carcinoma; Hepatocytes; Hepatoma; Humans; Liver; Liver cancer; Liver diseases; Liver Neoplasms - drug therapy; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Metastases; Metastasis; Methods; Molecular Targeted Therapy; Polyethylene glycol; Proteins; Researchers; Review; Ribonucleic acid; RNA; Signal Transduction; Tumors
• ISSN: 1476-4598; 1476-4598
• DOI: 10.1186/s12943-019-1085-0

Hepatocellular carcinoma (HCC) is the most commonmalignancy. Exsome plays a significant role in the elucidation of signal transduction pathways between hepatoma cells, angiogenesis and early diagnosis of HCC. Exosomes are small vesicular structures that mediate interaction between different types of cells, and contain a variety of components (including DNA, RNA, and proteins). Numerous studies have shown that these substances in exosomes are involved in growth, metastasis and angiogenesis in liver cancer, and then inhibited the growth of liver cancer by blocking the signaling pathway of liver cancer cells. In addition, the exosomal substances could also be used as markers for screening early liver cancer. In this review, we summarized to reveal the significance of exosomes in the occurrence, development, diagnosis and treatment of HCC, which in turn might help us to further elucidate the mechanism of exosomes in HCC, and promote the use of exosomes in the clinical diagnosis and treatment of HCC.