Zinc enhances the cellular energy supply to improve cell motility and restore impaired energetic metabolism in a toxic environment induced by OTA

• Published in: Scientific reports Vol. 7; no. 1; pp. 14669 - 11
• Main Authors: Yang, Xuan, Wang, Haomiao, Huang, Chuchu, He, Xiaoyun, Xu, Wentao, Luo, Yunbo, Huang, Kunlun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07-11-2017; Nature Publishing Group
• Subjects: 14/63; 631/92/1643; 692/700/2814; 82/80; 96/1; 96/34; Blotting, Western; Cancer; Carbohydrate metabolism; Cell Movement - drug effects; Cell Survival - drug effects; Deoxyribonucleic acid; DNA; Energy metabolism; Energy Metabolism - drug effects; HEK293 Cells - drug effects; HEK293 Cells - metabolism; Homeostasis; Humanities and Social Sciences; Humans; Lipid metabolism; Metabolism; Mitochondria; Motility; multidisciplinary; Nutrient deficiency; Ochratoxin A; Ochratoxins - pharmacology; Oxidative metabolism; Oxidative phosphorylation; Oxidative stress; Phosphorylation; Physiology; Pyruvic acid; Science; Science (multidisciplinary); Superoxide Dismutase - metabolism; Supplements; Zinc; Zinc - pharmacology
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-14868-x

Exogenous nutrient elements modulate the energetic metabolism responses that are prerequisites for cellular homeostasis and metabolic physiology. Although zinc is important in oxidative stress and cytoprotection processes, its role in the regulation of energetic metabolism remains largely unknown. In this study, we found that zinc stimulated aspect in cell motility and was essential in restoring the Ochratoxin A (OTA)-induced energetic metabolism damage in HEK293 cells. Moreover, using zinc supplementation and zinc deficiency models, we observed that zinc is conducive to mitochondrial pyruvate transport, oxidative phosphorylation, carbohydrate metabolism, lipid metabolism and ultimate energy metabolism in both normal and toxic-induced oxidative stress conditions
in vitro
, and it plays an important role in restoring impaired energetic metabolism. This zinc-mediated energetic metabolism regulation could also be helpful for DNA maintenance, cytoprotection and hereditary cancer traceability. Therefore, zinc can widely adjust energetic metabolism and is essential in restoring the impaired energetic metabolism of cellular physiology.