1,25-dihydroxyvitamin D deficiency is independently associated with cardiac valve calcification in patients with chronic kidney disease

• Published in: Scientific reports Vol. 12; no. 1; pp. 915 - 9
• Main Authors: Kim, Il Young, Ye, Byung Min, Kim, Min Jeong, Kim, Seo Rin, Lee, Dong Won, Kim, Hyo Jin, Rhee, Harin, Song, Sang Heon, Seong, Eun Young, Lee, Soo Bong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18-01-2022; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4022/1585/104; 692/499; Aged; Aortic valve; Aortic Valve - abnormalities; Aortic Valve - diagnostic imaging; Aortic Valve - pathology; Aortic Valve Stenosis; Blood pressure; Calcification; Calcification (ectopic); Calcinosis - blood; Calcium phosphates; Cardiovascular disease; Cardiovascular diseases; Coronary artery disease; Cross-Sectional Studies; Diabetes mellitus; Dialysis; Echocardiography; Female; Heart diseases; Heart Valve Diseases - blood; Heart Valve Diseases - complications; Humanities and Social Sciences; Humans; Kidney diseases; Kidneys; Male; Middle Aged; Mitral valve; Mitral Valve - diagnostic imaging; Mitral Valve - pathology; multidisciplinary; Parathyroid; Parathyroid hormone; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - complications; Rheumatic heart disease; ROC Curve; Science; Science (multidisciplinary); Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-04981-x

Cardiac valve calcification is highly prevalent in patients with chronic kidney disease (CKD). Low vitamin D levels are associated with vascular calcification in CKD. However, the association between vitamin D levels and cardiac valve calcification is unknown. A total of 513 patients with pre-dialysis CKD were included in this cross-sectional study. Aortic valve calcification (AVC) and mitral valve calcification (MVC) were assessed using two-dimensional echocardiography. The associations between AVC and MVC and baseline variables were investigated using logistic regression analyses. In multivariable analysis, serum 1,25(OH)
2
D level was independently associated with AVC (odds ratio [OR], 0.87; P < 0.001) and MVC (OR, 0.92; P < 0.001). Additionally, age, diabetes, coronary heart disease, calcium × phosphate product, and intact parathyroid hormone levels were independently associated with AVC and MVC. Systolic blood pressure was independently associated with AVC. A receiver-operating characteristic (ROC) curve analysis showed that the best cutoff values of serum 1,25(OH)
2
D levels for predicting AVC and MVC were ≤ 12.5 and ≤ 11.9 pg/dl, respectively. Serum 1,25(OH)
2
D deficiency is independently associated with AVC and MVC in patients with CKD, suggesting that serum 1,25(OH)
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D level may be a potential biomarker of AVC and MVC in these patients.