Prognostic role of nutritional status in elderly patients hospitalized for COVID-19: a monocentric study
Background Symptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection incidence is higher in the elderly patients. Pre-existing geriatric conditions such as comorbidity and frailty seem related to worse hospital outcomes. Aims To assess the role of nutritional status as an in...
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Published in: | Aging clinical and experimental research Vol. 32; no. 12; pp. 2695 - 2701 |
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Main Authors: | , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
Cham
Springer International Publishing
01-12-2020
Springer Nature B.V |
Subjects: | |
Online Access: | Get full text |
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Summary: | Background
Symptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection incidence is higher in the elderly patients. Pre-existing geriatric conditions such as comorbidity and frailty seem related to worse hospital outcomes.
Aims
To assess the role of nutritional status as an independent prognostic factor for in-hospital death in elderly patients.
Methods
Consecutive elderly patients (age > 65 years) hospitalized for novel coronavirus disease (COVID-19) were enrolled. Demographics, laboratory and comorbidity data were collected. Nutritional status was evaluated using the Geriatric Nutritional Risk Index (GNRI). Uni- and multivariate Cox regression analyses to evaluate predictors for in-hospital death were performed.
Results
One hundred and nine hospitalized elderly patients (54 male) were consecutively enrolled. At univariate analysis, age (HR 1.045 [CI 1.008–1.082]), cognitive impairment (HR 1.949 [CI 1.045–3.364]), C-reactive protein (HR 1.004 [CI 1.011–1.078]), lactate dehydrogenases (HR 1.003 [CI 1.001–1.004]) and GNRI moderate–severe risk category (HR 8.571 [CI 1.096–67.031]) were risk factors for in-hospital death, while albumin (HR 0.809 [CI 0.822–0.964]), PaO
2
/FiO
2
ratio (HR 0.996 [CI 0.993–0.999]) and body mass index (HR 0.875 [CI 0.782–0.979]) were protective factors. Kaplan–Meier survival curves showed a significative higher survival in patients without GNRI moderate or severe risk category (
p
= 0.0013).
At multivariate analysis, PaO
2
/FiO
2
ratio (HR 0.993 [CI 0.987–0.999],
p
= 0.046) and GNRI moderate–severe risk category (HR 9.285 [1.183–72.879],
p
= 0.034) were independently associated with in-hospital death.
Conclusion
Nutritional status assessed by GNRI is a significative predictor of survival in elderly patients hospitalized for COVID-19. The association between GNRI and PaO
2
/FiO
2
ratio is a good prognostic model these patients. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1720-8319 1594-0667 1720-8319 |
DOI: | 10.1007/s40520-020-01727-5 |