Evaluation of a Nanoemulsion-Based Formulation for Respiratory Delivery of Budesonide by Nebulizers

• Published in: AAPS PharmSciTech Vol. 11; no. 3; pp. 1147 - 1151
• Main Authors: Amani, Amir, York, Peter, Chrystyn, Henry, Clark, Brian J.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01-09-2010
• Subjects: Administration, Inhalation; Aerosols - administration & dosage; Aerosols - chemistry; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Drug Compounding - methods; Emulsions - chemical synthesis; Indexing in process; Materials Testing; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Nebulizers and Vaporizers; Pharmacology/Toxicology; Pharmacy; Research Article; Respiratory System Agents - administration & dosage; Respiratory System Agents - chemistry; budesonide; nebulizer; microemulsion; nanoemulsion; characterisation; suspension
• ISSN: 1530-9932; 1530-9932
• DOI: 10.1208/s12249-010-9486-9

The aim of this work was to evaluate the
in vitro
performance of a nebulized nanoemulsion formulation which had been optimised previously. To do so, a transparent nanoemulsion preparation containing 1.5 mg/ml of budesonide was prepared and diluted to achieve concentrations of 250 and 500 μg/ml budesonide. The
in vitro
characteristics of the diluted nanoemulsions were then compared with the commercially available suspension of budesonide (Pulmicort Respules®) when nebulized using a jet and a vibrating mesh nebulizer. A smaller MMAD with improved aerosol output was observed in the nanoemulsion preparations compared with the corresponding suspension formulations indicating an improved
in vitro
performance for the nanoemulsion-based preparations.