Antimicrobial resistance in colonizing group B Streptococcus among pregnant women from a hospital in Vietnam

• Published in: Scientific reports Vol. 11; no. 1; p. 20845
• Main Authors: Van Du, Vu, Dung, Pham Thai, Toan, Nguyen Linh, Van Mao, Can, Bac, Nguyen Thanh, Van Tong, Hoang, Son, Ho Anh, Thuan, Nghiem Duc, Viet, Nguyen Thanh
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21-10-2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/22; 631/326/41; 631/326/41/1470; 631/326/41/2531; 631/326/421; 692/308; 692/420; 692/499; 692/699; 692/699/255; 692/699/255/1318; Adult; Ampicillin; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotics; Antimicrobial agents; Antimicrobial resistance; Cefotaxime; Ceftriaxone; Clindamycin; Colonization; Dalfopristin; Drug resistance; Drug Resistance, Bacterial; Erythromycin; Female; Humanities and Social Sciences; Humans; Middle Aged; multidisciplinary; Multidrug resistance; Neonates; Penicillin; Phenotypes; Pregnancy; Pregnancy Complications, Infectious - drug therapy; Pregnancy Complications, Infectious - epidemiology; Pregnancy Complications, Infectious - microbiology; Prophylaxis; Quinupristin; Risk factors; Sampling; Science; Science (multidisciplinary); Streptococcal Infections - drug therapy; Streptococcal Infections - epidemiology; Streptococcal Infections - microbiology; Streptococcus; Streptococcus agalactiae - drug effects; Streptococcus infections; Vancomycin; Vietnam - epidemiology; Young Adult; β-Lactam antibiotics; Vietnam
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-00468-3

Few studies have been conducted on group B
Streptococcus
(GBS) in Vietnam. We determined the GBS colonization and antimicrobial resistance vaginal-rectal profile of 3863 Vietnamese pregnant women over 5 years. Maternal GBS colonization was characterized by antibiotic susceptibility. Overall, the GBS colonization rate was 8.02% (95% CI: 7.20–8.94%). Compared to sampling ≥ 35 weeks of gestation, the GBS colonization rate was statistically higher (
p
 = 0.004) with sampling < 35 weeks. Among 272 antimicrobial susceptibility testing isolates, all were susceptible to ampicillin, penicillin, ceftriaxone, cefotaxime, vancomycin, and quinupristin/dalfopristin. Resistance was highest for tetracycline (89.66%), followed by erythromycin (76.23%) and clindamycin (58.21%). Multidrug resistance and resistance to ≥ 6 different antibiotics were 60.66% and 8.82%, respectively. Resistance to clindamycin but not erythromycin (L phenotype) was 2.2%. The clindamycin resistance rate was significantly increased (
p
 = 0.005) during the study period. These data demonstrate a low rate of maternal GBS colonization. The high rate of erythromycin, clindamycin, and multidrug resistance to GBS that can be transmitted to neonates is an important risk factor to consider. β-lactams continue to be appropriate for first-line treatment and prophylaxis in the study area. Ongoing monitoring should be considered in the future.