Nanomaterial-Based Biosensors using Field-Effect Transistors: A Review

• Published in: Journal of electronic materials Vol. 51; no. 5; pp. 1950 - 1973
• Main Authors: Manimekala, T., Sivasubramanian, R., Dharmalingam, Gnanaprakash
• Format: Journal Article
• Language: English
• Published: New York Springer US 2022; Springer Nature B.V
• Subjects: Biomarkers; Biosensors; Characterization and Evaluation of Materials; Chemistry and Materials Science; Electronic devices; Electronics and Microelectronics; Field effect transistors; Instrumentation; Materials Science; Nanomaterials; Neurotransmitters; Nucleic acids; Optical and Electronic Materials; Portable equipment; Review; Review Article; Selectivity; Semiconductor devices; Sensitivity; Service life assessment; Solid State Physics; nanomaterial; glucose; carbon nanotubes; metal oxide; Bio-FET; silicon nanowire; nucleic acid; dopamine
• ISSN: 0361-5235; 1543-186X
• DOI: 10.1007/s11664-022-09492-z

Field-effect transistor biosensors (Bio-FET) have attracted great interest in recent years owing to their distinctive properties like high sensitivity, good selectivity, and easy integration into portable and wearable electronic devices. Bio-FET performance mainly relies on the constituent components such as the bio-recognition layer and the transducer, which ensures device stability, sensitivity, and lifetime. Nanomaterial-based Bio-FETs are excellent candidates for biosensing applications. This review discusses the basic concepts, function, and working principles of Bio-FETs, and focuses on the progress of recent research in Bio-FETs in the sensing of neurotransmitters, glucose, nucleic acids, proteins, viruses, and cancer biomarkers using nanomaterials. Finally, challenges in the development of Bio-FETs, as well as an outlook on the prospects of nano Bio-FET-based sensing in various fields, are discussed.