Convalescent plasma for COVID-19: the risk of pulmonary embolism should not be underestimated

The authors describe safety issues associated with the administration of convalescent plasma, reporting both non-specific (infection, circulatory overload, lung injury) and disease-specific (viral enhancement) side effects of plasma transfusions. [...]it is crucial to ascertain which (if) treatments...

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Bibliographic Details
Published in:	Critical care (London, England) Vol. 24; no. 1; pp. 1 - 531
Main Authors:	Sanfilippo, F, La Rosa, V, Oliveri, F, Astuto, M
Format:	Journal Article
Language:	English
Published:	London BioMed Central Ltd 28-08-2020 BioMed Central BMC
Subjects:	Clinical trials Coronaviruses COVID-19 Critical care Influenza Intensive care Letter Methylene blue Plasma Pulmonary embolism Pulmonary embolisms Italy
Online Access:	Get full text
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Summary:	The authors describe safety issues associated with the administration of convalescent plasma, reporting both non-specific (infection, circulatory overload, lung injury) and disease-specific (viral enhancement) side effects of plasma transfusions. [...]it is crucial to ascertain which (if) treatments during the preparation of convalescent plasma have been performed to reduce the amount of coagulation factors. [...]we believe that plasma transfusions should be administered thoughtfully in COVID-19 patients to avoid an unnecessary potentiation of their already existing pro-thrombotic state.
Bibliography:	SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 ObjectType-Commentary-2
ISSN:	1364-8535 1364-8535 1366-609X 1466-609X
DOI:	10.1186/s13054-020-03236-3