Reactive Oxygen Species-Related Nanoparticle Toxicity in the Biomedical Field

The unique physicochemical characteristics of nanoparticles have recently gained increasing attention in a diverse set of applications, particularly in the biomedical field. However, concerns about the potential toxicological effects of nanoparticles remain, as they have a higher tendency to generat...

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Bibliographic Details
Published in:	Nanoscale research letters Vol. 15; no. 1; p. 115
Main Authors:	Yu, Zhongjie, Li, Qi, Wang, Jing, Yu, Yali, Wang, Yin, Zhou, Qihui, Li, Peifeng
Format:	Journal Article
Language:	English
Published:	New York Springer US 20-05-2020 Springer Nature B.V SpringerOpen
Subjects:	Apoptosis Biocompatibility Biomedical materials Biomolecules Biotoxicity Carbonyls Chemistry and Materials Science Deoxyribonucleic acid DNA DNA damage Lipid peroxidation Lipids Materials Science Membrane structure Membrane structures Molecular Medicine Mutagenesis Nano Review Nanochemistry Nanoparticles Nanoscale Science and Technology Nanotechnology Nanotechnology and Microengineering Necrosis Oxidation Oxidative stress Peroxidation Reactive oxygen species Ribonucleic acid RNA Toxicity Nanoparticles Oxidative stress Reactive oxygen species Biotoxicity
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Summary:	The unique physicochemical characteristics of nanoparticles have recently gained increasing attention in a diverse set of applications, particularly in the biomedical field. However, concerns about the potential toxicological effects of nanoparticles remain, as they have a higher tendency to generate excessive amounts of reactive oxygen species (ROS). Due to the strong oxidation potential, the excess ROS induced by nanoparticles can result in the damage of biomolecules and organelle structures and lead to protein oxidative carbonylation, lipid peroxidation, DNA/RNA breakage, and membrane structure destruction, which further cause necrosis, apoptosis, or even mutagenesis. This review aims to give a summary of the mechanisms and responsible for ROS generation by nanoparticles at the cellular level and provide insights into the mechanics of ROS-mediated biotoxicity. We summarize the literature on nanoparticle toxicity and suggest strategies to optimize nanoparticles for biomedical applications.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1931-7573 1556-276X 1556-276X
DOI:	10.1186/s11671-020-03344-7