In Situ Electrospinning of "Dry-Wet" Conversion Nanofiber Dressings for Wound Healing

• Published in: Marine drugs Vol. 21; no. 4; p. 241
• Main Authors: Liu, Shanfei, Wu, Guilin, Wang, Wen, Wang, Heng, Gao, Yingjun, Yang, Xuhong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-04-2023; MDPI
• Subjects: Anti-Bacterial Agents - chemistry; Bandages; Bandages and bandaging; Biocompatibility; Biomedical materials; Care and treatment; Cell culture; Cell proliferation; Composite structures; Electric fields; Emergencies; Exudates; Exudation; Gas exchange; handheld electrospinning; Health aspects; Hydrogels; in situ deposition; Medical dressings; Morphology; nanofiber dressings; Nanofibers; Nanofibers - chemistry; Nanotechnology; Organic solvents; Permeability; Polymers; Polyvinyl alcohol; Proliferation; Properties; Skin; Solvents; Technology application; Tensile strain; Tensile strength; Wound Healing; Wounds and injuries; “dry-wet” conversion; China; handheld electrospinning; wound healing; “dry-wet” conversion; nanofiber dressings; in situ deposition
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md21040241

Rapid wound dressings provide an excellent solution strategy for the treatment of wounds in emergency situations. In this study, aqueous solvent-based PVA/SF/SA/GelMA nanofiber dressings fabricated by a handheld electrospinning device could deposit quickly and directly on the wound, perfectly fitting wounds with various sizes. Using an aqueous solvent overcame the disadvantage of using the current organic solvents as the medium for rapid wound dressings. The porous dressings had excellent air permeability to ensure smooth gas exchange at the wound site. The distribution range of the tensile strength of the dressings was 9-12 Kpa, and the tensile strain was between 60-80%, providing sufficient mechanical support during wound healing. The dressings could absorb 4-8 times their own weight in solution and could rapidly absorb wound exudates from wet wounds. The nanofibers formed ionic crosslinked hydrogel after absorbing exudates, maintaining the moist condition. It formed a hydrogel-nanofiber composite structure with un-gelled nanofibers and combined the photocrosslinking network to maintain a stable structure at the wound location. The in vitro cell culture assay indicated that the dressings had excellent cell cytocompatibility, and the addition of SF contributed to cell proliferation and wound healing. The in situ deposited nanofiber dressings had excellent potential in the urgent treatment of emergency wounds.