Effect of delayed anthrax vaccine dose on Bacillus anthracis protective antigen IgG response and lethal toxin neutralization activity

• Published in: Vaccine Vol. 31; no. 44; pp. 5009 - 5014
• Main Authors: Pittman, Phillip R, Fisher, Diana, Quinn, Xiaofei, Schmader, Trevor, Barrera-Oro, Julio G
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 17-10-2013; Elsevier
• Subjects: Adult; Allergy and Immunology; Anthrax; Anthrax - immunology; Anthrax - prevention & control; Anthrax Vaccines - administration & dosage; Anthrax Vaccines - immunology; Antibodies, Bacterial - immunology; Antibodies, Neutralizing - immunology; Antibody Formation; antigens; Antigens, Bacterial - immunology; Applied microbiology; AVA; Bacillus anthracis; Bacterial Toxins - immunology; Bacteriology; Biological and medical sciences; BioThrax® anthrax vaccine adsorbed; Enzyme-Linked Immunosorbent Assay; Fundamental and applied biological sciences. Psychology; Human antibody response to anthrax vaccine; Humans; Immunization Schedule; Immunization, Secondary; immunoglobulin G; Immunoglobulin G - immunology; Male; Microbiology; Middle Aged; Miscellaneous; neutralization; Neutralization Tests; vaccination; vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Young Adult; AVA; Human antibody response to anthrax vaccine; BioThrax ® anthrax vaccine adsorbed; BioThrax® anthrax vaccine adsorbed; Human; Bacillus anthracis; Immune response; IgG; Vaccine; Bacillaceae; Neutralizing antibody; Infection; Antigen; Toxin; Bacillales; Anthrax; Bacteriosis; Bacteria; BioThrax; anthrax vaccine adsorbed; Humoral immunity; BioThrax(®) anthrax vaccine adsorbed
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2013.08.086

Highlights • The persistence of anti-PA IgG antibody in humans two years after partial priming doses of anthrax vaccine is described. • Human anti-PA IgG antibody response to delayed doses of anthrax vaccine adsorbed is described. • Comparison of antibody response by ELISA and lethal toxin neutralization activity. • Evidence is presented supporting continuing the anthrax vaccination series when a dose is missed for as long as two years rather than restarting the series.