Tween-80 improves single/coaxial electrospinning of three-layered bioartificial blood vessel

• Published in: Journal of materials science. Materials in medicine Vol. 34; no. 1; pp. 6 - 15
• Main Authors: Wu, Chuang, Wang, Haixiang, Cao, Jin
• Format: Journal Article
• Language: English
• Published: New York Springer US 31-12-2022; Springer Nature B.V; Springer
• Subjects: Biocompatibility; Biomaterials; Biomaterials Synthesis and Characterisation; Biomechanics; Biomedical Engineering and Bioengineering; Biomedical materials; Blood vessels; Cell adhesion; Cell adhesion & migration; Cell culture; Ceramics; Chemistry and Materials Science; Collagen; Composites; Core-shell structure; Electrospinning; Ethanol; Extracellular matrix; FDA approval; Glass; In vivo methods and tests; Materials Science; Mechanical properties; Nanofibers; Nanofibers - chemistry; Natural Materials; Polyesters - chemistry; Polymer Sciences; Polysorbates; Regenerative Medicine/Tissue Engineering; Solvents; Surfaces and Interfaces; Surfactants; Tension tests; Thin Films; Tissue Engineering - methods; Tissue Scaffolds - chemistry
• ISSN: 1573-4838; 0957-4530; 1573-4838
• DOI: 10.1007/s10856-022-06707-x

Electrospinning is a promising technique for preparing bioartificial blood vessels. Nanofibers prepared by electrospinning can simulate the structure of extracellular matrix to promote cell adhesion and proliferation. However, thorn-like protrusions can appear as defects on electrospun scaffolds and coaxial electrospun nanofibers often have no clear core/shell structure, which can seriously affect the quality of bioartificial blood vessels. To address these problems, Tween 80 is added to the electrospinning solution, which results in a stable Taylor cone, eliminates the thorn-like protrusions on electrospun bioartificial blood vessels, and reduces interfacial effects due to different core/shell solutions during coaxial electrospinning. Simulations, biomechanical tests, and in vivo studies were performed. The results demonstrate the excellent mechanical properties and biocompatibility of the bioartificial blood vessel. This research provides a useful reference for optimizing the electrospinning process for fabricating bioartificial blood vessels.
Graphical Abstract