Homologous laminar organization of the mouse and human subiculum

• Published in: Scientific reports Vol. 11; no. 1; p. 3729
• Main Authors: Bienkowski, Michael S., Sepehrband, Farshid, Kurniawan, Nyoman D., Stanis, Jim, Korobkova, Laura, Khanjani, Neda, Clark, Kristi, Hintiryan, Houri, Miller, Carol A., Dong, Hong-Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12-02-2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/2583; 631/378/3920; Adult; Alzheimer's disease; Animals; Brain - metabolism; Brain - physiology; Brain Mapping - methods; Databases, Factual; Gene expression; Gene Expression - genetics; Gene Expression Profiling - methods; Gene Expression Regulation - genetics; Hippocampus; Hippocampus - metabolism; Hippocampus - physiology; Humanities and Social Sciences; Humans; Hybridization; Magnetic resonance imaging; Male; Mice; Middle Aged; multidisciplinary; Neural Pathways - metabolism; Neurodegenerative diseases; Neuroimaging; Pyramidal cells; Pyramidal Cells - metabolism; Science; Science (multidisciplinary); Subiculum; Transcriptome - genetics
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-81362-w

The subiculum is the major output component of the hippocampal formation and one of the major brain structures most affected by Alzheimer’s disease. Our previous work revealed a hidden laminar architecture within the mouse subiculum. However, the rotation of the hippocampal longitudinal axis across species makes it unclear how the laminar organization is represented in human subiculum. Using in situ hybridization data from the Allen Human Brain Atlas, we demonstrate that the human subiculum also contains complementary laminar gene expression patterns similar to the mouse. In addition, we provide evidence that the molecular domain boundaries in human subiculum correspond to microstructural differences observed in high resolution MRI and fiber density imaging. Finally, we show both similarities and differences in the gene expression profile of subiculum pyramidal cells within homologous lamina. Overall, we present a new 3D model of the anatomical organization of human subiculum and its evolution from the mouse.