Gray matter correlations of cognition in incident Parkinson's disease
We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region‐specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI)...
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Published in: | Movement disorders Vol. 25; no. 5; pp. 629 - 633 |
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Main Authors: | , , , , , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
15-04-2010
Wiley |
Subjects: | |
Online Access: | Get full text |
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Summary: | We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region‐specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel‐based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD. © 2010 Movement Disorder Society |
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Bibliography: | Potential conflict of interest: Nothing to report. Research Council of Norway - No. 177966 ArticleID:MDS22867 istex:DBF6FF96650F3C24E5371EC1814622AEE9053EE7 Dr. Larry D. Jacobs Fellowship Research Council of Norway - No. 186966 Western Norway Regional Health Authority - No. 911218 Norwegian Society of Radiology ark:/67375/WNG-FDKLQTBW-G ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0885-3185 1531-8257 1531-8257 |
DOI: | 10.1002/mds.22867 |