Gray matter correlations of cognition in incident Parkinson's disease

We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region‐specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI)...

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Published in:Movement disorders Vol. 25; no. 5; pp. 629 - 633
Main Authors: Dalaker, Turi O., Zivadinov, Robert, Larsen, Jan P., Beyer, Mona K., Cox, Jennifer L., Alves, Guido, Bronnick, Kolbjorn, Tysnes, Ole-Bjorn, Antulov, Ronald, Dwyer, Michael G., Aarsland, Dag
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15-04-2010
Wiley
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Summary:We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region‐specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel‐based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD. © 2010 Movement Disorder Society
Bibliography:Potential conflict of interest: Nothing to report.
Research Council of Norway - No. 177966
ArticleID:MDS22867
istex:DBF6FF96650F3C24E5371EC1814622AEE9053EE7
Dr. Larry D. Jacobs Fellowship
Research Council of Norway - No. 186966
Western Norway Regional Health Authority - No. 911218
Norwegian Society of Radiology
ark:/67375/WNG-FDKLQTBW-G
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0885-3185
1531-8257
1531-8257
DOI:10.1002/mds.22867