Self-reported short sleep duration and frequent snoring in pregnancy: impact on glucose metabolism

• Published in: American journal of obstetrics and gynecology Vol. 203; no. 2; pp. 142.e1 - 142.e5
• Main Authors: Facco, Francesca L., MD, Grobman, William A., MD, MBA, Kramer, Jamie, MD, Ho, Kim H., BS, Zee, Phyllis C., MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01-08-2010; Elsevier
• Subjects: Adult; Age Distribution; Biological and medical sciences; Blood Glucose - analysis; Cohort Studies; Comorbidity; Confidence Intervals; Diabetes, Gestational - diagnosis; Diabetes, Gestational - epidemiology; Female; Follow-Up Studies; Gestational Age; gestational diabetes; Glucose - metabolism; Glucose Intolerance; Glucose Tolerance Test - methods; Gynecology. Andrology. Obstetrics; Humans; Logistic Models; Medical sciences; Multivariate Analysis; Obstetrics and Gynecology; Pregnancy; Pregnancy Outcome; Prenatal Care - methods; Prenatal Diagnosis; Prevalence; Probability; Prospective Studies; Risk Assessment; Self Disclosure; sleep disorders in pregnancy; Sleep Wake Disorders - diagnosis; Sleep Wake Disorders - epidemiology; Snoring - diagnosis; Snoring - epidemiology; Young Adult; sleep disorders in pregnancy; glucose metabolism; gestational diabetes; Pregnancy; Sleep; Gynecology; Duration; Glucose; Metabolism; Obstetrics
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/j.ajog.2010.03.041

Objective We sought to evaluate the impact of short sleep duration (SSD) and frequent snoring (FS) on glucose metabolism during pregnancy. Study Design We conducted a prospective cohort study of healthy nulliparas who participated in a sleep survey study. SSD was defined as <7 hours of sleep per night and FS, as snoring ≥3 nights per week. Outcomes included 1-hour oral glucose tolerance results and the presence of gestational diabetes mellitus (GDM). Univariate and multivariate analyses were performed. Results A total of 189 women participated; 48% reported an SSD and 18.5% reported FS. SSD and FS were associated with higher oral glucose tolerance values: SSD (116 ± 31 vs 105 ± 23; P = .008) and FS (118 ± 34 vs 108 ± 25; P = .04). Both SSD (10.2% vs 1.1%; P = .008) and FS (14.3% vs 3.3%; P = .009) were associated with a higher incidence of GDM. Even after controlling for potential confounders, SSD and FS remained associated with GDM. Conclusion SSD and FS are associated with glucose intolerance in pregnancy.