Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet

• Published in: Nutrients Vol. 13; no. 6; p. 1999
• Main Authors: Kravchenko, Lidia V, Aksenov, Ilya V, Nikitin, Nikolay S, Guseva, Galina V, Avrenyeva, Ludmila I, Trusov, Nikita V, Balakina, Anastasia S, Tutelyan, Victor A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-06-2021; MDPI
• Subjects: Accumulation; Adipose tissue; Animals; Antioxidants; Automation; Biomarkers - metabolism; Body weight; Body Weight - drug effects; Cholesterol; Choline; Diet; Enzymes; Extinction; Fatty liver; Feeding Behavior; Food; Glutathione peroxidase; hypercaloric choline-deficient diet; Inflammation; Lipid Metabolism - drug effects; Lipid peroxidation; Lipids; Lipoic acid; Liver; Liver - drug effects; Liver - pathology; Liver diseases; liver lipid accumulation; Male; Males; Medical research; Medicine, Experimental; non-alcoholic fatty liver disease; Nutrient deficiency; Nutrition research; Organ Size - drug effects; Oxidative stress; Oxidative Stress - drug effects; Paraoxonase; Peroxidase; Plasma; Proteins; Rats; Rats, Wistar; Thioctic Acid - adverse effects; Transaminase; Triglycerides; Type 2 diabetes; α-lipoic acid; Finland; α-lipoic acid; non-alcoholic fatty liver disease; liver lipid accumulation; hypercaloric choline-deficient diet; oxidative stress
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu13061999

Non-alcoholic fatty liver disease (NAFLD) is currently estimated as the most prevalent chronic liver disease in all age groups. An increasing body of evidence obtained in experimental and clinical data indicates that oxidative stress is the most important pathogenic factor in the development of NAFLD. The study aimed to investigate the impact of α-lipoic acid (LA), widely used as an antioxidant, on the effects of a hypercaloric choline-deficient diet. Male Wistar rats were divided into three groups: control diet (C); hypercaloric choline-deficient diet (HCCD), and hypercaloric choline-deficient diet with α-lipoic acid (HCCD+LA). Supplementation of HCCD with LA for eight weeks led to a decrease in visceral adipose tissue/body weight ratio, the activity of liver glutathione peroxidase and paraoxonase-1, plasma, and liver total antioxidant activity, as well as an increase in liver/body weight ratio, liver total lipid and triglyceride content, and liver transaminase activities compared to the HCCD group without LA. In conclusion, our study shows that α-lipoic acid detains obesity development but exacerbates the severity of diet-induced oxidative stress and lipid accumulation in the liver of male Wistar rats fed a hypercaloric choline-deficient diet.