Metabolomics Analysis of Cistus monspeliensis Leaf Extract on Energy Metabolism Activation in Human Intestinal Cells

• Published in: Journal of biomedicine & biotechnology Vol. 2012; no. 2012; pp. 1 - 7
• Main Authors: Shimoda, Yoichi, Han, Junkyu, Kawada, Kiyokazu, Smaoui, Abderrazak, Isoda, Hiroko
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 01-01-2012; Hindawi Publishing Corporation
• Subjects: Adenosine Triphosphate - metabolism; Antioxidants - pharmacology; ATP; Caco-2 Cells; Cell Survival - drug effects; Cistus - chemistry; Cistus monspeliensis; Citric Acid Cycle - drug effects; Energy Metabolism - drug effects; Glycolysis - drug effects; Humans; Intestines - cytology; Intestines - drug effects; Intestines - metabolism; Metabolome - drug effects; Metabolomics; Plant Extracts - pharmacology; Plant Leaves - chemistry
• ISSN: 1110-7243; 1110-7251
• DOI: 10.1155/2012/428514

Energy metabolism is a very important process to improve and maintain health from the point of view of physiology. It is well known that the intracellular ATP production is contributed to energy metabolism in cells. Cistus monspeliensis is widely used as tea, spices, and medical herb; however, it has not been focusing on the activation of energy metabolism. In this study, C. monspeliensis was investigated as the food resources by activation of energy metabolism in human intestinal epithelial cells. C. monspeliensis extract showed high antioxidant ability. In addition, the promotion of metabolites of glycolysis and TCA cycle was induced by C. monspeliensis treatment. These results suggest that C. monspeliensis extract has an ability to enhance the energy metabolism in human intestinal cells.