Novel Nanocomposite Hydrogels Based on Crosslinked Microbial Polysaccharide as Potential Bioactive Wound Dressings

• Published in: Materials Vol. 16; no. 3; p. 982
• Main Authors: Marin, Maria Minodora, Albu Kaya, Madalina, Kaya, Durmus Alpaslan, Constantinescu, Roxana, Trica, Bogdan, Gifu, Ioana Catalina, Alexandrescu, Elvira, Nistor, Cristina Lavinia, Alexa, Rebeca Leu, Ianchis, Raluca
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20-01-2023; MDPI
• Subjects: antimicrobial; Bacteria; Bacterial infections; Bandages and bandaging; Biocompatibility; Biological activity; Biopolymers; Care and treatment; Coliforms; Composition; Crosslinking; E coli; Gels (Pharmacy); Hydrogels; Infections; Laboratories; Mechanical properties; Microbial polysaccharides; Microorganisms; Nanocomposites; Nanomedicine; Nanoparticles; Phenols; polysaccharide; Polysaccharides; salecan; Scanning electron microscopy; Scientific imaging; Silver; silver nanoparticles; Skin; Sulfur; Synthesis; Thermogravimetric analysis; Thermomechanical properties; Transmission electron microscopy; Wound healing; Wounds and injuries; Romania; Bucharest Romania; United States > US; Germany; antimicrobial; hydrogels; polysaccharide; silver nanoparticles; salecan
• ISSN: 1996-1944; 1996-1944
• DOI: 10.3390/ma16030982

A multitude of dressings have been developed to promote wound repair, such as membranes, foams, hydrocolloids and hydrogels. In this study, a crosslinked polysaccharide hydrogel was mixed with a bioactive ingredient to synthesize a novel nanocomposite material to be used in wound healing. Variation of the ratio between hydrogel components was followed and its effect was analyzed in regard to swelling, degradation rate and thermo-mechanical behavior. The resulting crosslinked structures were characterized by FTIR and microscopy analyses. The antimicrobial activity of the crosslinked hydrogels loaded with bioactive agent was evaluated using two bacterial strains (Gram-positive Staphylococcus aureus and Gram-negative bacteria Escherichia Coli). All the results showed that the new synthesized biopolymer nanocomposites have adequate properties to be used as antibacterial wound dressings.