Autoimmune progesterone dermatitis manifesting as generalized fixed drug eruption

Autoimmune progesterone dermatitis manifesting as generalized fixed drug eruption

Autoimmune progesterone dermatitis is an uncommon, poorly recognized and under-diagnosed catamenial dermatosis associated with hypersensitivity reactions to progestagens. Most cases manifest as urticaria, eczema or erythema multiforme-like. A 26-year-old woman developed violaceous plaques on the gro...

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Bibliographic Details
Published in:Anais brasileiros de dermatología Vol. 93; no. 6; pp. 874 - 877
Main Authors: Carrasco-Zuber, Juan Eduardo, Álvarez-Véliz, Sergio, Moll-Manzur, Catherina, González--Bombardiere, Sergio
Format: Journal Article
Language:English
Published: Spain Elsevier España, S.L.U 01-11-2018
Sociedade Brasileira de Dermatologia
Subjects:
Adult
Allergy and immunology
Autoimmune diseases
Autoimmune Diseases - diagnosis
Case Report
Dermatitis
Dermatitis - diagnosis
DERMATOLOGY
Drug eruptions
Drug Eruptions - diagnosis
Female
Humans
Hypersensitivity
Progesterone - adverse effects
Allergy and immunology
Drug eruptions
Autoimmune diseases
Dermatitis
Hypersensitivity
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Summary:Autoimmune progesterone dermatitis is an uncommon, poorly recognized and under-diagnosed catamenial dermatosis associated with hypersensitivity reactions to progestagens. Most cases manifest as urticaria, eczema or erythema multiforme-like. A 26-year-old woman developed violaceous plaques on the groin and abdomen, 4 days after a spontaneous abortion resolved with uterine curettage. The lesions recurred once monthly at the same sites, mimicking a fixed drug eruption. Although the histopathology was compatible with fixed drug eruption, positive intradermal testing and symptomatic improvement after using oral contraceptive pills gave us a clue to the diagnosis.
ISSN:0365-0596
1806-4841
1806-4841
DOI:10.1590/abd1806-4841.20187290