Venous occlusion to the lower limb attenuates vasoconstriction in the nonexercised limb during posthandgrip muscle ischemia

• Published in: Journal of applied physiology (1985) Vol. 96; no. 3; pp. 981 - 984
• Main Authors: Tokizawa, K, Mizuno, M, Nakamura, Y, Muraoka, I
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01-03-2004; American Physiological Society
• Subjects: Adult; Analysis of Variance; Biological and medical sciences; Blood pressure; Cardiology; Exercise; Forearm - blood supply; Forearm - physiology; Fundamental and applied biological sciences. Psychology; Hand Strength - physiology; Humans; Ischemia - physiopathology; Leg - blood supply; Leg - physiology; Lower Extremity - blood supply; Lower Extremity - physiology; Male; Muscle, Skeletal - blood supply; Muscle, Skeletal - physiology; Muscular system; Physical Exertion - physiology; Vascular Resistance - physiology; Vasoconstriction - physiology; Venous Thrombosis - physiopathology; Occlusion; Nervous system diseases; Chemoreflex; muscle chemoreflex; Vasoconstriction; Calf; Lower limb; Cardiovascular disease; Ox; Striated muscle; calf volume; Blood flow; Vascular disease; Vasomotricity; Vertebrata; Mammalia; Ischemia; Vascular resistance; Artiodactyla; Hemodynamics; Ungulata
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.00695.2003

1 Graduate School of Human Sciences and 2 School of Sport Sciences, Waseda University, Saitama 359-1192, Japan
Submitted 7 July 2003
; accepted in final form 25 October 2003
We investigated the effects of increases in calf volume on cardiovascular responses during handgrip (HG) exercise and post-HG exercise muscle ischemia (PEMI). Seven subjects completed two trials: one control (no occlusion) and one venous occlusion (VO) session. Both trials included a baseline measurement followed by 15 min of rest (REST), 2 min of HG, and 2 min of PEMI. VO was applied at 100 mmHg via cuffs placed around both distal thighs during REST, HG, and PEMI. Mean arterial pressure, heart rate, forearm blood flow (FBF) in the nonexercised arm, and forearm vascular resistance (FVR) in the nonexercised arm (FVR) were measured. During REST and HG, there were no significant differences between trials in all parameters. During PEMI in the control trial, mean arterial pressure and FVR were significantly greater and FBF was significantly lower than baseline values ( P < 0.05 for each). In contrast, in the VO trial, FBF and FVR responses were different from control responses. In the VO trial, FBF was significantly greater than in the control trial (4.7 ± 0.5 vs. 2.5 ± 0.3 ml·100 ml -1 ·min -1 , P < 0.05) and FVR was significantly lower (28.0 ± 4.8 vs. 49.1 ± 4.6 units, respectively, P < 0.05). These results indicate that increases in vascular resistance in the nonexercised limb induced by activation of the muscle chemoreflex can be attenuated by increases in calf volume.
calf volume; blood flow; vascular resistance; muscle chemoreflex
Address for reprint requests and other correspondence: I. Muraoka, School of Sport Sciences, Waseda Univ., Mikajima 2-579-15, Tokorozawa, Saitama 359-1192, Japan (E-mail: imuraoka{at}waseda.jp ).