Dietary iron and haem iron intake and risk of endometrial cancer: a prospective cohort study

• Published in: British journal of cancer Vol. 98; no. 1; pp. 194 - 198
• Main Authors: Kabat, G C, Miller, A B, Jain, M, Rohan, T E
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15-01-2008; Nature Publishing Group
• Subjects: Adult; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Body mass index; Canada - epidemiology; Cancer Research; Cohort analysis; Cohort Studies; Diabetes; Drug Resistance; Endometrial cancer; Endometrial Neoplasms - epidemiology; Epidemiology; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Heme; Hormone replacement therapy; Humans; Insulin resistance; Iron; Iron, Dietary; Meat; Medical research; Medical sciences; Middle Aged; Molecular Medicine; Oncology; Population; Prospective Studies; Questionnaires; Risk Factors; Surveys and Questionnaires; Tumors; Womens health; Canada; metabolic syndrome; dietary iron; cohort study; body mass index; hormone replacement therapy; haem iron; endometrial neoplasms; red meat; Endocrinopathy; Endometrium cancer; Cardiovascular disease; Iron; Metabolic syndrome; Epidemiology; Meat; Prospective; Body mass index; Cancerology; Uterus; Cohort study; Female genital system; Uterine diseases; Endometrium; Nutrition; Metabolic diseases; Malignant tumor; Feeding; Female genital diseases; Diet; Risk factor; Hormone replacement therapy; Cancer
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/sj.bjc.6604110

We used data from a large cohort study of Canadian women to assess the association of meat intake and dietary intake of iron and haem iron with risk of endometrial cancer. Among 34 148 women with an intact uterus at baseline and followed for a mean of 16.4 years, we identified 426 incident endometrial cancer cases. Data from a food frequency questionnaire administered at baseline were used to calculate intake of all meats, red meat, total dietary iron, iron from meat, haem iron, and non-haem iron. Analyses were carried out using Cox proportional hazards models with adjustment for known risk factors and covariates. We found no association of intake of meat or any of the dietary iron-related variables with risk of endometrial cancer.