Persistence of HIV-1 Transmitted Drug Resistance Mutations

• Published in: The Journal of infectious diseases Vol. 208; no. 9; pp. 1459 - 1463
• Main Authors: Castro, Hannah, Pillay, Deenan, Cane, Patricia, Asboe, David, Cambiano, Valentina, Phillips, Andrew, Dunn, David T.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01-11-2013
• Subjects: Adolescent; Adult; Anti-HIV Agents - pharmacology; Anti-HIV Agents - therapeutic use; Biological and medical sciences; Drug resistance; Drug Resistance, Viral - genetics; Female; Fundamental and applied biological sciences. Psychology; Genetic mutation; HIV; HIV 1; HIV Infections - drug therapy; HIV Infections - virology; HIV-1 - drug effects; HIV-1 - genetics; HIV/AIDS; Hospital units; Human immunodeficiency virus 1; Humans; Infections; Infectious diseases; Major and Brief Reports; Male; Medical sciences; Memory interference; Microbiology; Miscellaneous; Teaching hospitals; Virology; Viruses; Young Adult; Virus; Infection; Resistance; HIV-1 virus; Retroviridae; Human immunodeficiency virus; Mutation; Lentivirus; HIV-1; persistence; mutations; transmitted; resistance
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/jit345

There are few data on the persistence of individual human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) mutations in the absence of selective drug pressure. We studied 313 patients in whom TDR mutations were detected at their first resistance test and who had a subsequent test performed while ART-naive. The rate at which mutations became undetectable was estimated using exponential regression accounting for interval censoring. Most thymidine analogue mutations (TAMs) and T215 revertants (but not T215F/Y) were found to be highly stable, with NNRTI and PI mutations being relatively less persistent. Our estimates are important for informing HIV transmission models.