Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

• Published in: Materials Vol. 12; no. 3; p. 465
• Main Authors: Ansari, Shoeb Anwar Mohammed Khawja, Ficiarà, Eleonora, Ruffinatti, Federico Alessandro, Stura, Ilaria, Argenziano, Monica, Abollino, Ornella, Cavalli, Roberta, Guiot, Caterina, D'Agata, Federico
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02-02-2019; MDPI
• Subjects: Bibliographic literature; Biocompatibility; biomedical applications; Biomedical materials; Cell membranes; Central nervous system; Decomposition; Iron; iron oxide nanoparticles; Iron oxides; Lipids; magnetic nanoparticles; Magnetic properties; Methods; Nanoparticles; Nervous system; Organic chemistry; Review; Size distribution; Surfactants; Synthesis; Toxicity; synthesis; magnetic nanoparticles; iron oxide nanoparticles; biomedical applications; central nervous system
• ISSN: 1996-1944; 1996-1944
• DOI: 10.3390/ma12030465

Magnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range of applications. During recent years, one of the most challenging goals is the development of new strategies to finely tune the unique properties of MNPs, in order to improve their effectiveness in the biomedical field. This review provides an up-to-date overview of the methods of synthesis and functionalization of MNPs focusing on Iron Oxide Nanoparticles (IONPs). Firstly, synthesis strategies for fabricating IONPs of different composition, sizes, shapes, and structures are outlined. We describe the close link between physicochemical properties and magnetic characterization, essential to developing innovative and powerful magnetic-driven nanocarriers. In conclusion, we provide a complete background of IONPs functionalization, safety, and applications for the treatment of Central Nervous System disorders.