Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects

Promoting the functional maturation of the desired cell types derived from human pluripotent stem cells （hPSCs） remains a major challenge, especially for hepatocytes, as routine access to metabolically functional hepatocytes would enable their use in drug toxicity screening. Although previous attemp...

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Bibliographic Details
Published in:	Cell research Vol. 23; no. 1; pp. 157 - 161
Main Authors:	Zhao, Dongxin, Chen, Song, Duo, Shuguang, Xiang, Chengang, Jia, Jun, Guo, Mina, Lai, Wei, Lu, Shichun, Deng, Hongkui
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-01-2013 Nature Publishing Group
Subjects:	631/136/532/1360 631/532/2064 692/698/2741/288/2032 Biomedical and Life Sciences Cell Biology Cell Differentiation Cells, Cultured Hepatocyte Nuclear Factor 3-beta - genetics Hepatocyte Nuclear Factor 3-beta - metabolism Hepatocyte Nuclear Factor 4 - genetics Hepatocyte Nuclear Factor 4 - metabolism Hepatocyte Nuclear Factor 6 - genetics Hepatocyte Nuclear Factor 6 - metabolism Hepatocytes - cytology Hepatocytes - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Letter to the Editor Life Sciences Pluripotent Stem Cells - cytology Stem cells Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism 人类多能干细胞多能性成熟纠正细胞代谢缺陷肝细胞
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Summary:	Promoting the functional maturation of the desired cell types derived from human pluripotent stem cells （hPSCs） remains a major challenge, especially for hepatocytes, as routine access to metabolically functional hepatocytes would enable their use in drug toxicity screening. Although previous attempts to induce hepatic specification from hPSCs yielded cells possessing some hepatic features,
Bibliography:	Promoting the functional maturation of the desired cell types derived from human pluripotent stem cells （hPSCs） remains a major challenge, especially for hepatocytes, as routine access to metabolically functional hepatocytes would enable their use in drug toxicity screening. Although previous attempts to induce hepatic specification from hPSCs yielded cells possessing some hepatic features 31-1568/Q SourceType-Other Sources-1 ObjectType-Article-2 content type line 63 ObjectType-Correspondence-1 These two authors contributed equally to this work.
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2012.144