Effects of metformin on the reproductive system of androgenized female rats

• Published in: Fertility and sterility Vol. 95; no. 4; pp. 1507 - 1509
• Main Authors: Mahamed, Roberta Rassi, M.D, Maganhin, Carla Cristina, M.D., Ph.D, Simões, Ricardo Santos, M.D, de Jesus Simões, Manuel, M.D., Ph.D, Baracat, Edmund Chada, M.D., Ph.D, Soares, José Maria, M.D., Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15-03-2011; Elsevier
• Subjects: Androgenized rats; animal ovaries; Animals; Biological and medical sciences; Female; Female genital diseases; glucose; Gynecology. Andrology. Obstetrics; homeostasis; Insulin Resistance - physiology; Internal Medicine; Male; Medical sciences; metformin; Metformin - pharmacology; Metformin - therapeutic use; Non tumoral diseases; Obstetrics and Gynecology; polycystic ovary syndrome; Rats; Rats, Wistar; Reproduction - drug effects; Reproduction - physiology; reproductive system; testosterone; Virilism - chemically induced; Virilism - drug therapy; Virilism - metabolism; metformin; reproductive system; Androgenized rats; polycystic ovary syndrome; Rat; Gynecology; Rodentia; Female sterility; Polycystic ovary; Obstetrics; Female genital diseases; Ovarian diseases; Vertebrata; Hypoglycemic agent; Biguanides; Mammalia; Animal; Cyst; Female; Benign neoplasm; Metformin; Reproductive system
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2010.07.1093

Metformin improved the glucose rate and the homeostasis model assessment–insulin resistance (HOMA-IR) index and caused partial reversion of ovaries and uterine morphology in female rats androgenized with testosterone.