Green tea catechin induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2 (TRPM2)

The major polyphenols in green tea, (−)-epigallocatechin and (−)-epigallocatechin gallate, have been shown to enhance the phagocytic activity of macrophage-like cells; however, the mechanism involved was not clarified. In this study, we have identified that the catechins induced phagocytosis can be...

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Bibliographic Details
Published in:	Cytotechnology (Dordrecht) Vol. 66; no. 4; pp. 561 - 566
Main Authors:	Monobe, Manami, Ema, Kaori, Tokuda, Yoshiko, Maeda-Yamamoto, Mari
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-08-2014 Springer Nature B.V
Subjects:	Biochemistry Biomedicine Biotechnology Brief Report Catalase Catechin Chemistry Chemistry and Materials Science Epigallocatechin gallate Green tea Hydrogen peroxide Life sciences Macrophages Phagocytes Phagocytosis Polyphenols Tea Transient receptor potential proteins United States > US Japan (−)-Epigallocatechin (EGC) (−)-Epigallocatechin gallate (EGCG) TRPM2 Hydrogen peroxide Phagocytosis
Online Access:	Get full text
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Summary:	The major polyphenols in green tea, (−)-epigallocatechin and (−)-epigallocatechin gallate, have been shown to enhance the phagocytic activity of macrophage-like cells; however, the mechanism involved was not clarified. In this study, we have identified that the catechins induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0920-9069 1573-0778
DOI:	10.1007/s10616-013-9618-7