Thulium fiber laser: the new player for kidney stone treatment? A comparison with Holmium:YAG laser

• Published in: World journal of urology Vol. 38; no. 8; pp. 1883 - 1894
• Main Authors: Traxer, Olivier, Keller, Etienne Xavier
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-08-2020; Springer Nature B.V; Springer Verlag
• Subjects: Calculi; Equipment Design; Humans; Invited Review; Kidney Calculi - surgery; Kidney stones; Kidneys; Laser Therapy - instrumentation; Laser Therapy - methods; Lasers; Lasers, Solid-State - therapeutic use; Life Sciences; Lithotripsy; Medicine; Medicine & Public Health; Nephrolithiasis; Nephrology; Oncology; Thulium - therapeutic use; Urology; Innovation; Holmium:YAG laser; Thulium fiber laser; Lithotripsy; Urinary stone
• ISSN: 0724-4983; 1433-8726
• DOI: 10.1007/s00345-019-02654-5

Purpose
To compare the operating modes of the Holmium:YAG laser and Thulium fiber laser. Additionally, currently available literature on Thulium fiber laser lithotripsy is reviewed.
Materials and methods
Medline, Scopus, Embase, and Web of Science databases were searched for articles relating to the operating modes of Holmium:YAG and Thulium fiber lasers, including systematic review of articles on Thulium fiber laser lithotripsy.
Results
The laser beam emerging from the Holmium:YAG laser involves fundamental architectural design constraints compared to the Thulium fiber laser. These differences translate into multiple potential advantages in favor of the Thulium fiber laser: four-fold higher absorption coefficient in water, smaller operating laser fibers (50–150 µm core diameter), lower energy per pulse (as low as 0.025 J), and higher maximal pulse repetition rate (up to 2000 Hz). Multiple comparative in vitro studies suggest a 1.5–4 times faster stone ablation rate in favor of the Thulium fiber laser.
Conclusions
The Thulium fiber laser overcomes the main limitations reported with the Holmium:YAG laser relating to lithotripsy, based on preliminary in vitro studies. This innovative laser technology seems particularly advantageous for ureteroscopy and may become an important milestone for kidney stone treatment.