New advances in genitourinary cancer: evidence gathered in 2014

• Published in: Cancer and metastasis reviews Vol. 34; no. 3; pp. 443 - 464
• Main Authors: Suárez, C., Puente, J., Gallardo, E., Méndez-Vidal, M. J., Climent, M. A., León, L., Olmos, D., García del Muro, X., González-Billalabeitia, E., Grande, E., Bellmunt, J., Mellado, B., Maroto, P., González del Alba, A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-09-2015; Springer; Springer Nature B.V
• Subjects: Antimitotic agents; Antineoplastic agents; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Care and treatment; Clinical; Development and progression; Humans; Metastasis; Oncology; Oncology, Experimental; Prostate cancer; Urogenital Neoplasms - therapy; Zoledronic acid; Molecular research; Genitourinary cancer; Renal cancer; Bladder cancer; Prostate cancer; Germ cell tumors
• ISSN: 0167-7659; 1573-7233
• DOI: 10.1007/s10555-015-9577-x

This review provides updated information published in 2014 regarding advances and major achievements in genitourinary cancer. Sections include the best in prostate cancer, renal cancer, bladder cancer, and germ cell tumors. In the field of prostate cancer, data related to treatment approach of hormone-sensitive disease, castrate-resistant prostate cancer, mechanisms of resistance, new drugs, and molecular research are presented. In relation to renal cancer, relevant aspects in the treatment of advanced renal cell carcinoma, immunotherapy, and molecular research, including angiogenesis and von Hippel-Lindau gene, molecular biology of non-clear cell histologies, and epigenetics of clear renal cell cancer are described. New strategies in the management of muscle-invasive localized bladder cancer and metastatic disease are reported as well as salient findings of biomolecular research in urothelial cancer. Some approaches intended to improve outcomes in poor prognosis patients with metastatic germ cell cancer are also reported. Results of clinical trials in these areas are discussed.