Effects of sildenafil and vardenafil treatments on sleep quality and depression in hemodialysis patients with erectile dysfunction

• Published in: International journal of impotence research Vol. 23; no. 1; pp. 27 - 31
• Main Authors: Solak, Y, Atalay, H, Kan, S, Kaynar, M, Bodur, S, Yeksan, M, Turk, S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-01-2011; Nature Publishing Group
• Subjects: 631/378; 692/699/2768/1575; 692/700/565/1436; 692/700/565/1950/1544; Adult; Adult and adolescent clinical studies; Analysis; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Cross-Over Studies; Depression; Depressive Disorder - complications; Depressive Disorder - physiopathology; Depressive Disorder - psychology; Dosage and administration; Drug therapy; Emergency and intensive care: renal failure. Dialysis management; Erectile dysfunction; Erectile Dysfunction - complications; Erectile Dysfunction - drug therapy; Erectile Dysfunction - physiopathology; Erectile Dysfunction - psychology; Gynecology. Andrology. Obstetrics; Hemodialysis; Humans; Imidazoles - therapeutic use; Impotence; Intensive care medicine; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - physiopathology; Kidney Failure, Chronic - psychology; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Mood disorders; original-article; Phosphodiesterase 5 Inhibitors - therapeutic use; Physiological aspects; Piperazines - therapeutic use; Prospective Studies; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Purines - therapeutic use; Renal Dialysis; Reproductive Medicine; rology; Self Report; Sildenafil; Sildenafil Citrate; Sleep; Sleep - drug effects; Sulfones - therapeutic use; Surveys and Questionnaires; Treatment Outcome; Triazines - therapeutic use; Urology; Vardenafil Dihydrochloride; Turkey; depression; vardenafil; sildenafil; sleep quality; erectile dysfunction; Andrology; Vasodilator agent; 3',5'-Cyclic-GMP phosphodiesterase; Hemodialysis; Esterases; Vardenafil; Phosphoric diester hydrolases; Extrarenal dialysis; Quality; Male genital diseases; Mood disorder; Human; Erection disorders; Enzyme; Depressions; Enzyme inhibitor; Depression; Phosphodiesterase inhibitor; Phosphodiesterase 5 inhibitor; Sleep; Treatment; Hydrolases; Sildenafil
• ISSN: 0955-9930; 1476-5489
• DOI: 10.1038/ijir.2010.32

ED is prevalent in hemodialysis (HD) patients, and closely related to poor sleep and depression. Efficacy of treating ED either with sildenafil or vardenafil has been shown to be beneficial in ameliorating concomitant depression in non-HD patients. It is yet to be shown whether treatment of ED with a PDE-5 inhibitor would improve poor sleep in HD patients. We aimed to compare the effects of sildenafil and vardenafil on sleep quality and depression in HD patients with ED. A total of 32 maintenance HD patients with ED randomized into two groups to receive either sildenafil or vardenafil for 4 weeks. After a 2-week washout and a crossover, each group received the other drug for another 4-week period. Sleep quality and depression were evaluated via post-sleep inventory (PSI) and Beck's depression inventory (BDI), respectively, at baseline and at the end of the treatment. Sildenafil and vardenafil both improved PSI and BDI scores significantly compared with pretreatment values. However, there was no difference between sildenafil and vardenafil with respect to these parameters. PDE-5 inhibitors, sildenafil and vardenafil, caused a significant improvement in sleep quality and depression in this cohort of HD patients with ED.