Increased incidence trend of low-grade and high-grade neuroendocrine neoplasms

• Published in: Endocrine Vol. 58; no. 2; pp. 368 - 379
• Main Authors: Leoncini, Emanuele, Boffetta, Paolo, Shafir, Michail, Aleksovska, Katina, Boccia, Stefania, Rindi, Guido
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-11-2017; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Diabetes; Endocrinology; Epidemiology; Female; Humanities and Social Sciences; Humans; Incidence; Internal Medicine; Male; Medicine; Medicine & Public Health; Middle Aged; Minority & ethnic groups; multidisciplinary; Neoplasm Grading; Neuroendocrine tumors; Neuroendocrine Tumors - epidemiology; Neuroendocrine Tumors - pathology; Original; Original Article; Prevalence; Science; SEER Program; Surveillance; Trends; Tumors; United States - epidemiology; United States > US; High-grade; Neuroendocrine; Low-grade; Cancer; Incidence
• ISSN: 1355-008X; 1559-0100
• DOI: 10.1007/s12020-017-1273-x

Purpose
The incidence of neuroendocrine neoplasms is increasing. This work aimed at: (i) establishing worldwide incidence trend of low-grade neuroendocrine neoplasms; (ii) defining the incidence and temporal trend of high-grade neuroendocrine neoplasms in USA utilizing the Surveillance Epidemiology and End Results database; (iii) comparing trends for low-grade vs. high-grade neuroendocrine neoplasms.
Methods
We conducted a literature search on MEDLINE and Scopus databases and incidence trends were plotted for 1973-2012. The Surveillance Epidemiology and End Results database was used to identify incidence rates in USA for 1973-2012. Incidence rates were stratified according to histological grade, gender and ethnicity. Trends were summarized as annual percent change and corresponding 95% confidence interval.
Results
11 studies were identified involving 72,048 cases; neuroendocrine neoplasm incidence rates increased over time in all countries for all sites, except for appendix. In Surveillance Epidemiology and End Results low-grade neuroendocrine neoplasm incidence rate increased from 1.09 in 1973 to 3.51 per 100,000 in 2012. During this interval, high-grade neuroendocrine neoplasm incidence rate increased from 2.54 to 10.52 per 100,000. African Americans had the highest rates of digestive neuroendocrine neoplasms with male prevalence in high-grade.
Conclusions
Our data indicate an increase in the incidence of neuroendocrine neoplasms as a worldwide phenomenon, affecting most anatomical sites and involving both low-grade and high-grade neoplasms.