The association between metabolic syndrome components and the development of atherosclerosis

• Published in: Journal of human hypertension Vol. 33; no. 12; pp. 844 - 855
• Main Authors: Aboonabi, Anahita, Meyer, Roselyn Rose’, Singh, Indu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-12-2019; Nature Publishing Group
• Subjects: 692/499; 692/700/459/1748; Arteriosclerosis; Atherosclerosis; Atherosclerosis - blood; Atherosclerosis - epidemiology; Atherosclerosis - physiopathology; Atherosclerosis - therapy; Biomarkers - blood; Blood Coagulation; Blood Glucose - metabolism; Development and progression; Diet, Atherogenic - adverse effects; Disease Progression; Dyslipidemias - blood; Dyslipidemias - epidemiology; Dyslipidemias - physiopathology; Epidemiology; Health Administration; Humans; Hyperglycemia; Hyperglycemia - blood; Hyperglycemia - epidemiology; Hyperglycemia - physiopathology; Hypertension; Hypertension - epidemiology; Hypertension - physiopathology; Inflammation; Inflammation - blood; Inflammation - epidemiology; Inflammation - physiopathology; Inflammation Mediators - blood; Insulin Resistance; Lipids - blood; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - epidemiology; Metabolic Syndrome - physiopathology; Metabolic Syndrome - therapy; Obesity - blood; Obesity - epidemiology; Obesity - physiopathology; Oxidative Stress; Prognosis; Public Health; Review Article; Risk Assessment; Risk Factors; Sedentary Behavior; Type 2 diabetes
• ISSN: 0950-9240; 1476-5527
• DOI: 10.1038/s41371-019-0273-0

Metabolic syndrome (MetS) is a collection of pathological conditions associated with metabolic, pro-inflammatory, and prothrombotic states. MetS plays an essential role in the atherosclerotic process with associated clustering of risk factors which can increase the risk of atherogenic damage. There is an association between MetS components and the progression of atherosclerosis, which is the leading cause of cardiovascular deaths. This review was undertaken to assess the potential role of metabolic syndrome components, including oxidative stress, hypertension, hyperglycaemia and insulin resistance, obesity, dyslipidemia, chronic inflammation, physical inactivity, and atherogenic diet in the progression of atherosclerosis based on existing research.