Protective effect of rutin against spatial memory impairment induced by trimethyltin in rats

• Published in: Nutrition research (New York, N.Y.) Vol. 28; no. 9; pp. 629 - 634
• Main Authors: Koda, Tomoko, Kuroda, Yoshiki, Imai, Hideki
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-09-2008; Tarrytown, N.Y.: Elsevier Science Inc; Elsevier Science
• Subjects: animal models; Animals; Biological and medical sciences; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Gastroenterology and Hepatology; health promotion; Hippocampus; Hippocampus - drug effects; Hippocampus - pathology; Male; Maze Learning - drug effects; Memory; Memory Disorders - chemically induced; Memory Disorders - pathology; Memory Disorders - prevention & control; N-methyl- d-aspartate; neurons; neuroprotective effect; NMDA; Organ Size; plant-based foods; PLSD; protected least-squares difference; protective effect; Pyramidal Cells - drug effects; Pyramidal Cells - pathology; Rats; Rats, Sprague-Dawley; Rutin; Rutin - administration & dosage; tin; Trimethyltin; Trimethyltin Compounds - administration & dosage; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Memory; N-methyl- d-aspartate; Rats; NMDA; PLSD; protected least-squares difference; Rutin; Trimethyltin; Hippocampus; Memory disorder; Cognitive disorder; Rat; Rodentia; Central nervous system; Encephalon; Rutin; Memory; Trimethyltin; Rats; Hippocampus NMDA. N-methyl-D-aspartate: PLSD; Vertebrata; Mammalia; Animal; protected least-squares; Spatial memory
• ISSN: 0271-5317; 1879-0739
• DOI: 10.1016/j.nutres.2008.06.004

Rutin is a flavonoid with various biological activities that are beneficial to human health. Trimethyltin is a toxic organotin compound, and rats injected with trimethyltin serve as a useful in vivo model for studying spatial memory impairment and neurodegeneration in the hippocampus. The protective effect of rutin against the trimethyltin-induced spatial memory impairment and hippocampal neuron damage in rats was examined. Peroral administration of a single dose of trimethyltin (8.5 mg/kg) induced spatial memory loss and the extensive loss of CA3 pyramidal neurons in hippocampi, as indicated by the results of a Morris water maze task and histologic examination, respectively. Prolonged supplementation of rutin significantly reversed the trimethyltin-induced spatial memory impairment and the damage to pyramidal neurons in the hippocampal CA3b region, indicating an antioxidative effect of rutin. These results suggest that rutin in the diet may provide a protective effect against spatial memory impairment accompanied by hippocampal pyramidal neuron loss.