Unique SARS-CoV protein nsp1: bioinformatics, biochemistry and potential effects on virulence

Viruses have evolved a myriad of strategies for promoting viral replication, survival and spread. Sequence analysis of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) genome predicts several proteins that are unique to SARS-CoV. The search to understand the high virulence of SARS-CoV co...

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Bibliographic Details
Published in:	Trends in microbiology (Regular ed.) Vol. 15; no. 2; pp. 51 - 53
Main Authors:	Connor, Ramsey F, Roper, Rachel L
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-02-2007
Subjects:	Animals Computational Biology Humans Internal Medicine RNA - metabolism RNA, Messenger - metabolism SARS coronavirus SARS Virus - pathogenicity SARS Virus - physiology Severe Acute Respiratory Syndrome - metabolism Severe Acute Respiratory Syndrome - virology Viral Nonstructural Proteins - physiology Virulence Virus Replication
Online Access:	Get full text
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Summary:	Viruses have evolved a myriad of strategies for promoting viral replication, survival and spread. Sequence analysis of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) genome predicts several proteins that are unique to SARS-CoV. The search to understand the high virulence of SARS-CoV compared with related coronaviruses, which cause lesser respiratory illnesses, has recently focused on the unique nsp1 protein of SARS-CoV and suggests evolution of a possible new virulence mechanism in coronaviruses. The SARS-CoV nsp1 protein increases cellular RNA degradation and thus might facilitate SARS-CoV replication or block immune responses.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2006.12.005