Immune response to Bordetella pertussis is associated with season and undernutrition in Senegalese children

• Published in: Vaccine Vol. 32; no. 27; pp. 3431 - 3437
• Main Authors: Gaayeb, Lobna, Pinçon, Claire, Cames, Cécile, Sarr, Jean-Biram, Seck, Modou, Schacht, Anne-Marie, Remoué, Franck, Hermann, Emmanuel, Riveau, Gilles
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 05-06-2014; Elsevier
• Subjects: Africa; Allergy and Immunology; Anthropometry; Antibodies, Bacterial - blood; Applied microbiology; Bacteriology; Biological and medical sciences; Birth season; Bordetella pertussis; Child; Child, Preschool; Environment; Female; Fundamental and applied biological sciences. Psychology; Humans; Immunity; Immunity, Humoral; Immunoglobulin G - blood; Infant; Longitudinal Studies; Male; Malnutrition; Malnutrition - immunology; Microbiology; Miscellaneous; Multivariate Analysis; Nutritional Status; Pertussis Toxin - immunology; Pertussis Vaccine - immunology; Seasons; Senegal; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Africa; Senegal; Birth season; Environment; Bordetella pertussis; Malnutrition; Immunity; Africa; Human; Immune response; Nutrition disorder; Bacteria; Child
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2014.03.086

Highlights • Birth season and undernutrition modulated children's humoral response to pertussis toxin. • Response to Bordetella pertussis was dependent on age, village and time of visit. • Environmental factors modulate children's response to pertussis infection or vaccination.