Minimal Tissue Reaction after Chronic Subdural Electrode Implantation for Fully Implantable Brain-Machine Interfaces

• Published in: Sensors (Basel, Switzerland) Vol. 21; no. 1; p. 178
• Main Authors: Yan, Tianfang, Kameda, Seiji, Suzuki, Katsuyoshi, Kaiju, Taro, Inoue, Masato, Suzuki, Takafumi, Hirata, Masayuki
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29-12-2020; MDPI
• Subjects: animal model; Animals; Biocompatibility; Biosensing Techniques; Brain research; Brain-Computer Interfaces; brain–machine interface; chronic tissue reaction; Dogs; Electrocorticography; Electrodes; Electrodes, Implanted; Electroencephalography; Electronic implants; Evaluation; Head; implantable device; Implantation; Man-machine interfaces; Neurons; subdural electrode; Surgical implants; Titanium; Transplants & implants; United States > US; Japan; implantable device; brain–machine interface; chronic tissue reaction; subdural electrode; animal model
• ISSN: 1424-8220; 1424-8220
• DOI: 10.3390/s21010178

There is a growing interest in the use of electrocorticographic (ECoG) signals in brain-machine interfaces (BMIs). However, there is still a lack of studies involving the long-term evaluation of the tissue response related to electrode implantation. Here, we investigated biocompatibility, including chronic tissue response to subdural electrodes and a fully implantable wireless BMI device. We implanted a half-sized fully implantable device with subdural electrodes in six beagles for 6 months. Histological analysis of the surrounding tissues, including the dural membrane and cortices, was performed to evaluate the effects of chronic implantation. Our results showed no adverse events, including infectious signs, throughout the 6-month implantation period. Thick connective tissue proliferation was found in the surrounding tissues in the epidural space and subcutaneous space. Quantitative measures of subdural reactive tissues showed minimal encapsulation between the electrodes and the underlying cortex. Immunohistochemical evaluation showed no significant difference in the cell densities of neurons, astrocytes, and microglia between the implanted sites and contralateral sites. In conclusion, we established a beagle model to evaluate cortical implantable devices. We confirmed that a fully implantable wireless device and subdural electrodes could be stably maintained with sufficient biocompatibility in vivo.