In Vitro Interaction of Lithium on Phospholipids in Human Erythrocytes
ABSTRACT Lithium salts are used in the treatment of mania and as prophylaxis against manic depressive disorder. The aim of these studies was the in vitro investigation of the effect of lithium on phospholipids of human erythrocyte membranes. Erythrocytes were treated with lithium for 1 h. Phospholip...
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| Published in: | Toxicology mechanisms and methods Vol. 18; no. 6; pp. 515 - 517 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Informa UK Ltd
01-07-2008
Taylor & Francis Informa Healthcare |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | ABSTRACT
Lithium salts are used in the treatment of mania and as prophylaxis against manic depressive disorder. The aim of these studies was the in vitro investigation of the effect of lithium on phospholipids of human erythrocyte membranes. Erythrocytes were treated with lithium for 1 h. Phospholipids phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylocholine (PC) were separated from erythrocyte ghosts and determined by HPLC. Blood samples from healthy adults were investigated. A very strong decrease in PC content in erythrocyte membranes due to lithium in vitro treatment was found, as well as a statistically significant increase in PI content. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1537-6516 1537-6524 |
| DOI: | 10.1080/15376510701623961 |