MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth

Highlights ► MiR-503 simultaneously down-regulates expression of FGF2 and VEGFA and inhibits tumor angiogenesis and growth. ► MiR-503 expression is dramatically down-regulated in tumors by epigenetic hypermethylation of its promoter/regulatory region. ► This study identifies a novel miRNA-based alte...

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Bibliographic Details
Published in:	Cancer letters Vol. 333; no. 2; pp. 159 - 169
Main Authors:	Zhou, Bisheng, Ma, Ruihua, Si, Wenxia, Li, Sisi, Xu, Yan, Tu, Xin, Wang, Qing
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 10-06-2013 Elsevier Limited
Subjects:	3' Untranslated Regions Angiogenesis Animals Base Sequence carcinogenesis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cardiovascular disease Cell division Cloning Colleges & universities DNA Methylation Down-Regulation Enzymes Epigenetics Female FGF2 Fibroblast Growth Factors - genetics Gene expression Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Human Umbilical Vein Endothelial Cells - pathology Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Liver cancer Liver Neoplasms - genetics Liver Neoplasms - pathology Methylation Mice Mice, Inbred BALB C microRNA MicroRNAs MicroRNAs - genetics miR-503 Molecular Sequence Data Mutagenesis neoplasms Neovascularization, Pathologic - genetics Neovascularization, Pathologic - pathology Plasmids Promoter Regions, Genetic Tumors Vascular Endothelial Growth Factor A - genetics VEGFA Xenograft Model Antitumor Assays Angiogenesis fibroblast growth factor-b HCC Methylation vascular endothelial growth factor A FGF2 HIF1α miR-503 hypoxia inducible transcription factor 1α VEGFA hepatocellular carcinomas
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Summary:	Highlights ► MiR-503 simultaneously down-regulates expression of FGF2 and VEGFA and inhibits tumor angiogenesis and growth. ► MiR-503 expression is dramatically down-regulated in tumors by epigenetic hypermethylation of its promoter/regulatory region. ► This study identifies a novel miRNA-based alternative mechanism by which hypoxia increases expression of FGF2 and VEGFA.
Bibliography:	http://dx.doi.org/10.1016/j.canlet.2013.01.028 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.01.028