Genetic Susceptibility to Chronic Kidney Disease: Links, Risks and Management

• Published in: International journal of nephrology and renovascular disease Vol. 16; pp. 1 - 15
• Main Authors: Sawaf, Hanny, Gudura, Tariku T, Dorobisz, Sylvester, Sandy, Dianne, Wang, Xiangling, Bobart, Shane A
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01-01-2023; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Aneurysms; Biopsy; Blood pressure; Calcinosis; chronic kidney disease; Chronic kidney failure; Congenital defects; Congenital diseases; cystic kidney disease; Cysts; Development and progression; Disease susceptibility; end stage kidney disease; Epidemiology; Etiology; Family medical history; Genetic aspects; Genetic disorders; genetics; Hypertension; Kidney diseases; Kidney stones; Kinases; Liver; Morbidity; Mutation; Nephrolithiasis; Polyuria; Proteins; Renal replacement therapy; Review; Risk factors; Steroids; Transcription factors; Transplants & implants; Ultrasonic imaging; Urinary tract; chronic kidney disease; cystic kidney disease; genetics; end stage kidney disease
• ISSN: 1178-7058; 1178-7058
• DOI: 10.2147/IJNRD.S363041

Chronic kidney disease (CKD) is associated with significant morbidity and mortality worldwide. In recent years, our understanding of genetic causes of CKD has expanded significantly with several renal conditions having been identified. This review discusses the current landscape of genetic kidney disease and their potential treatment options. This review will focus on cystic kidney disease, glomerular disease with genetic associations, congenital anomalies of kidneys and urinary tract (CAKUT), autosomal dominant-tubulointerstitial kidney disease (ADTKD), inherited nephrolithiasis and nephrocalcinosis.