Chronic stress-induced memory deficits are reversed by regular exercise via AMPK-mediated BDNF induction

• Published in: Neuroscience Vol. 324; pp. 271 - 285
• Main Authors: Kim, D.-M, Leem, Y.-H
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 02-06-2016
• Subjects: Aminoimidazole Carboxamide - analogs & derivatives; Aminoimidazole Carboxamide - pharmacology; AMP-Activated Protein Kinases - metabolism; AMPK; Animals; BDNF; Brain-Derived Neurotrophic Factor - metabolism; Cells, Cultured; Chronic Disease; chronic restraint stress; Disease Models, Animal; Dose-Response Relationship, Drug; Exercise Therapy; Hippocampus - drug effects; Hippocampus - physiopathology; learning and memory; Male; Maze Learning - physiology; Memory Disorders - etiology; Memory Disorders - physiopathology; Memory Disorders - therapy; Mice, Inbred C57BL; Neurogenesis - physiology; Neurology; Nootropic Agents - pharmacology; Restraint, Physical; Ribonucleotides - pharmacology; Running - physiology; Running - psychology; Stress, Psychological - complications; Stress, Psychological - physiopathology; Stress, Psychological - therapy; treadmill running; BBB; ACTH; 5-amimoimidazole-4-carboxamide riboside; HPX; blood–brain barrier; post-synaptic density-95; treadmill running; brain-derived neurotrophic factor; phospho-AMPK; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; BDNF; hypothalamic–pituitary–adrenal; phosphorylated-AMPK; adrenocorticotrophic hormone; chronic restraint stress; EGTA; CORT; learning and memory; HEPES; AMPK; adenosine monophosphate-activated protein kinase; AICAR; corticosterone; ethylene glycol tetraacetic acid; PSD-95
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2016.03.019

Highlights • Chronic stress causes hippocampal-dependent memory deficit. • Exercise improves memory in chronically stressed mice. • Chronic stress reduces hippocampal AMPK activity, BDNF, and neurogenesis. • Exercise enhances hippocampal AMPK activity in chronically stressed mice. • AMPK is required for exercise-exerted memory and neurogenesis enhancement.