Reduced phosphorylation of synapsin I in the hippocampus of Engrailed-2 knockout mice, a model for autism spectrum disorders

• Published in: Neuroscience Vol. 286; pp. 122 - 130
• Main Authors: Provenzano, G, Pangrazzi, L, Poli, A, Sgadò, P, Berardi, N, Bozzi, Y
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 12-02-2015
• Subjects: Animals; autism; Child Development Disorders, Pervasive - genetics; Child Development Disorders, Pervasive - metabolism; Child Development Disorders, Pervasive - psychology; Disease Models, Animal; Down-Regulation; ERK; Female; Hippocampus - metabolism; Homeodomain Proteins - genetics; learning; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; mouse; Nerve Tissue Proteins - genetics; Neurology; neurotransmission; Phosphorylation; Signal Transduction; Spatial Learning - physiology; synapse; Synapsins - metabolism; SynII; synapsin II; Morris water maze; SynI; En2; pyr; learning; pyramidal cell layer; phosphorylated ERK; mouse; ASD; mossy fibers; synapsin I; Engrailed-2; mf; autism spectrum disorders; phosphorylated synapsin I; extracellular-regulated kinase; stratum lacunosum moleculare; RT-qPCR; WT; p-ERK; p-SynI; MWM; neurotransmission; granule cell layer; CA1/CA2/CA3; synapse; autism; hippocampal pyramidal cell layers; GCL; stratum radiatum; Cdk5; slm; γ-aminobutyric acid; s.r; quantitative reverse-transcription polymerase chain reaction; GABA; cyclin-dependent kinase 5; wild-type; ERK
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.11.041

Highlights • Synapsin I mRNA and protein are down-regulated in the hippocampus of En2−/− mice. • Synapsin I phosphorylation is reduced in the En2−/− hippocampus, both before and after spatial learning. • Different signaling pathways downstream of neurofibromin regulate synapsin I phosphorylation in the En2−/− hippocampus.