Memantine improves buprenorphine/naloxone treatment for opioid dependent young adults

Highlights • Evaluation of combining memantine with brief buprenorphine pharmacotherapy. • Randomized double-blind placebo-controlled study to assess treatment alternative for young adults. • Memantine 30 mg reduced relapse and opioid use after discontinuation of buprenorphine. • Memantine enhanced...

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Bibliographic Details
Published in:	Drug and alcohol dependence Vol. 156; pp. 243 - 253
Main Authors:	Gonzalez, Gerardo, DiGirolamo, Gregory, Romero-Gonzalez, Mauricio, Smelson, David, Ziedonis, Douglas, Kolodziej, Monika
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01-11-2015
Subjects:	Adolescent Adult Buprenorphine Buprenorphine, Naloxone Drug Combination - therapeutic use Dose-Response Relationship, Drug Double-Blind Method Early relapse Female Humans Male Memantine Memantine - therapeutic use Naloxone - therapeutic use Narcotic Antagonists - therapeutic use Opiate Substitution Treatment - methods Opioid dependence Opioid-Related Disorders - rehabilitation Psychiatry Recurrence Young Adult Young adults Opioid dependence Memantine Young adults Buprenorphine Early relapse
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Summary:	Highlights • Evaluation of combining memantine with brief buprenorphine pharmacotherapy. • Randomized double-blind placebo-controlled study to assess treatment alternative for young adults. • Memantine 30 mg reduced relapse and opioid use after discontinuation of buprenorphine. • Memantine enhanced treatment with buprenorphine/naloxone in young adults.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0376-8716 1879-0046
DOI:	10.1016/j.drugalcdep.2015.09.020